Scientists in Aging Research

Questions for October 6 - Control of cell proliferation: aging, cancer and p53.

1. Dr. Hayflick's paper in Experimental Cell Research was rejected for publication many times before it was finally accepted for publication. Why was this?

2. Why did Seshadri and Campisi conclude in their 1990 paper that repression of c-fos transcription was the only good candidate in their experiments for being causative in irreversible growth arrest in human fibroblasts?

3. Why do eukaryotic chromosomes shorten each time a cell divides?

4. Why are senescent cells 'good citizens', but 'bad neighbors'?

5. p53 promotes apoptosis, but inhibits cell proliferation. How could you explain the observations that a particular p53 mutant mouse develops aging phenotypes prematurely, but is resistant to spontaneous tumor formation, considering that mutations in p53 are found in many human tumors, and that cancer is a very common cause of death in mice?

(Huber will update the syllabus for weeks 6 - 15 this coming weekend).

Here you may access material to be discussed on Oct 6, 2008

Seshadri T, 1990

Tyner SD, 2002

Campisi J, 2005

Hayflick L, 1965

Harley CB, 1990

Beausejour CM, 2006

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Download Announcement

Scientists in Aging Research Fall Symposium

Featured Talk

Does Aging Make Fat go MAD?

By

James Kirkland, MD, PhD, Mayo Clinic

Followed by:
POSTER SESSION and RECEPTION

September 25, 2008
Talk at 4:45 PM, Reception 5:45 – 7:00 PM
Nils Hasselmo Hall 2-101

Snacks and refreshments will be served

Submit a Poster: Please send your maximum 300 word abstract to Marilyn Eells eells001@umn.edu at the Center on Aging (612-624-1185) by:

Wednesday September 16th

Maximum poster dimensions are 5 x 6 feet (height x width).
Posters set up in the Atrium starting at 4:30 pm.

FAQs

1. Is Jim Kirkland going to be available to meet before or after the event?
Answer: He may be available before the event, depending on how early he arrives.

2. Can I use an old poster?
Answer: Yes, as long as it meets the required dimensions. We do not have larger boards.

3. Do I have to be a SAR member to present a poster?
Answer: The poster session is open to all researchers regardless of their affiliation with SAR

4. Are posters made with individual panels (sheets) allowed?
Answer: Yes.

Posted by arriaga at 5:47 AM | Permalink | Comments (0)

The questions for Week 4 (Sept 29, 2008) are:

1. The level of many hormones, including growth hormone, decrease with age. What do you think of the general strategy of doing growth hormone replacement in older humans to rejuvenate them?

2. Would you generally recommend growth hormone therapy for people born as dwarfs, midgets, etc?.

Here you may access literature to be discussed on Sep 29, 2008

Brown-Borg, 1996

Coschigano, 2003

Suh, 2008

Tissenbaum & Guarente, 2001

Posted by arriaga at 3:27 AM | Permalink | Comments (0)

Download syllabus here

Posted by arriaga at 6:45 PM | Permalink | Comments (0)

The questions for Week 3 (Sept 22, 2008) are:

1. Other than lifespan extension, what common feature ties together the observations about mutations in age-1 and daf-2, and the inhibition of mTOR?

2. What explanations are there for the pleiotrophic effects of age-1 mutations?

3. What scientific progress occurred after the paper published by Freidman and Johnson in 1987, that facilitated the paper published by Morris et al. in1996?

4. What role does the protein product of daf-16 play in understanding the paper by Kenyon et al.

5. How does any of the above relate to the nutritional status of an organism?

Here you may access literature to be discussed on Sep 22, 2008

Frieman and Johnson, 1988

Kenyon et al., 1993

Kimura et al., 1997

Morris et al., 1996

Posted by arriaga at 6:08 PM | Permalink | Comments (0)