Scientists in Aging Research

Here are the links:

Van REmmen, 2003

Warner, 2007

Time, damage and ageing : what really matters? Rejuvenation Res. 10:373-375 is not accessible through library, We should ask Warner to send us this paper.

Here are the questions that Huber prepared for November 3. Would someone be willing to send Edgar the links to directly access reading materials?

1. Suggest an explanation for why SOD-deficient mice are viable, but fibroblasts taken from such mice are not when grown in air.

2. What is the significance of increased levels of plasma alanine aminotransferase activity in mice exposed to diaquat?

3. How do Han et al. explain the changes in gene expression patterns observed in diquat-treated mice?

4. Would you predict that GPx1-deficient mice would be short-lived? What about SOD2-deficient mice?

5. Should we consider the 'free radical theory of aging' disproved by evidence that oxidative damage and tumor incidence in mice can increase significantly without affecting life span?

---------------------------------------------------------------------------
Please add Hansen et al., 2008 to the reading list for November 10. I have listed 6 articles in all, but I hope you will read all of these more for their 'flavor' rather than for the details.

Posted by arriaga at 2:35 PM | Permalink | Comments (0)

Here you can download at least two of the three articles that will be discussed on October 20.

Beckman and Ames 1998

Miggliaccio 1999

This paper requires windows XP, internet explorer, or mozilla.
Giogio 2005

Posted by arriaga at 1:55 AM | Permalink | Comments (0)

Additional questions for Oct 13, 2008. Please refer to questions posted one week earlier.

6. How does the cell prevent oxidative damage to proteins?

7. How does the cell repair oxidized proteins?

8. What special role do methionine side chains play in protein oxidative damage?

9. Why might unscheduled DNA repair be relevant to life span?

Here you can download at least two of the three articles that will be discussed on October 13.

Stadtman, 1992

Shart and Setlow, 1974, 1992

You may be able to obtain Harman 1956 if you have a subscription for Science/AAAS or you request a free subscription. The link is

Harman, 1956

Posted by arriaga at 9:58 PM | Permalink | Comments (0)