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Links for downloading references are:
Here are the questions for the Nov 24, 2008 class.
1. Suggest at least one age-related pathology that may be caused by changes in the potential of stem cells to differentiate and replace lost cells.
2. In what ways might stem cells grow old?
3. What role(s) might DNA damage play in stem cell aging?
4. What problems need to be solved before considering stem cell therapy for a specific age-related pathology?
Here are the questions for Nov 17. Sorry for posting them late. I just realized it when I started to browse through the papers for tomorrow's class.
1. What are the goals of the NIA's Intervention Testing Program (ITP)? What was a major criticism of the early results obtained, and published, by the ITP investigators?
2. Why was it important for Bodnar et al. to demonstrate that cells with increased levels of transgenically-generated telomerase catalytic subunit had a normal karyotype?
3. What are sirtuins, and what proteins do they act on?
4. In the study by Baur et al., which changes summarized in Table 1 are most likely to contribute to extended life span in resveratrol-fed animals?
Here are the links for the references that will be discussed on Nov 17.
These are the questions for November 10, 2008
1. What was the major conclusion from the McCay paper?
2. Why did Miller use genetically heterogeneous mice for his experiments on predictors of longevity? What was his main conclusion?
3. What is a biomarker of aging? Why are biomarkers of aging highly sought?
4. What are the goals of the NIA's Intervention Testing Program (ITP)? What was a major criticism of the early results obtained, and published, by the ITP investigators?
5. What is autophagy? Why might it be beneficial?
6. What effect might rapamycin have on life span in mice?
References to review follow.
Warner 2004
(This one was on the end of last weeks questions to add for this week).
Hanson2004