Scientists in Aging Research

Here are the questions for Nov 17. Sorry for posting them late. I just realized it when I started to browse through the papers for tomorrow's class.

1. What are the goals of the NIA's Intervention Testing Program (ITP)? What was a major criticism of the early results obtained, and published, by the ITP investigators?

2. Why was it important for Bodnar et al. to demonstrate that cells with increased levels of transgenically-generated telomerase catalytic subunit had a normal karyotype?

3. What are sirtuins, and what proteins do they act on?

4. In the study by Baur et al., which changes summarized in Table 1 are most likely to contribute to extended life span in resveratrol-fed animals?

Here are the links for the references that will be discussed on Nov 17.

Hadley EC et al, 2005

Baur JA et al, 2006

Bodnar AG et al, 1998

Pearson , 2008. Select pages 157-168