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October 31, 2011

Lecture 24 - Normal and Reverse Phase Chromatography, Part 2


October 29, 2011

Seminars - John Yates III - November 7, 8, 10

Because Professor Yates is giving three seminars. Please start your comment with the date of the lecture.

Professor John Yates III
Department of Chemical Physiology
The Scripps Research Institute, La Joya, CA

Lecture 1: November 7, 2011
Time: 3:45 PM
Room: 100 Smith Hall
Using Mass spectrometry to understand protein misfolding diseases

Lecture 2: November 8, 2011
Time: 9:45 AM
Room: 331 Smith Hall
Interpreting mass spectrometry bar codes - The horse that pulls the cart

Lecture 3: November 10, 2011
Time: 9:45 PM
Room: 331 Smith Hall
Going big time - large scale in vivo proteomics to study disease

Seminar link: http://www.chem.umn.edu/seminar/

Midterm 2 Homework Answer Keys

Lecture 14 HW Key.pdf
Lecture 15 HW Key.pdf
Lecture 16 HW Key.pdf
Lecture 17 HW Key.pdf
Lecture 18 HW Key.pdf
Lecture 19 HW Key.pdf
Lecture 20 HW Key.pdf
Lecture 21 HW Key.pdf
Lecture 22 HW Key.pdf
Lecture 23 HW Key.pdf

Lecture 24 HW will be posted on Monday.

Lecture 24 HW Key.pdf



October 28, 2011

BlOG8 - Sample preparation

Please note that the due date is before the beginning of the exam next Friday (Hint!)


Lecture 23 - Normal and Reverse Phase Chromatography

We will use these notes on Monday October 31


October 27, 2011

Seminar - Daniel Chiu - October 27, 2011

Monday, October 3, 2011

Professor Daniel Chiu
Department of Chemistry
University of Washington, Seattle, WA

Time: 9:45 PM
Room: 331 Smith Hall

What can we do with and learn from a single cell?

Seminar link: http://www.chem.umn.edu/seminar/

Lecture 22 - Gas Chromatography

We will likely start with these lecture notes on Friday Oct 28.


October 24, 2011

Lecture 21 - Chromatography-Definitions

This set of lecture notes have a large number of suggested exercises. Make sure that you allocate sufficient time to work on them prior to exam 2.


Answers to Suggested Homeworks

Hello everyone,

Answers for the suggested homeworks in lectures for exam 2 will be posted on Friday.


Mass Spec Facilities - Visit, October 26, 2011

Mass Spec Facilities Visit - 2011.pdf

Date: October 26, 2011
Time: 8:15 to 8:45
Location: 191C Kolthoff Hall
Facility Director: Dr. Joe Dalluge

Similar to seminars, bonus points will be given to those posting in the blog after attendance to this facility visit.

Answer only one of the questions below.

1. What ionization sources are available?
2. What mass analyzers exist in the facility?
3. What instruments are interfaced with HPLC or other separation techniques?
4. What are projects currently using the facilities?
5. Are there any other ionization sources or mass analyzers in the facility that we did not cover in class?
6. What instrument(s) at the facility can be used to investigate your analytical problem?
7. If none of the instruments at the facility is suitable to investigate your analytical problem, what instrument would you say is needed to investigate your analytical problem.
8. What questions do you have that were not answered?

October 21, 2011

Friday Office Hour for 10/21 and 10/28

Hello everyone,

I will not hold office hours for today and next Friday (Oct. 28th) as they overlap with seminars.

If you need to see me, please email me and we will setup a 1-on-1 meeting. I do still have office hours on Monday at 8AM and will continue Friday, November 4th at 11AM.


October 20, 2011

Lecture 20 - Mass Spectrometry-Applications

These are the lecture notes for October 24. Please note that there are table assignments.


BlOG7 - Atomic and mass spectrometries


Postings are due on October 28, before class

Lecture 19 - Mass Spectrometry-II


Lecture notes for Friday October 21

Blog 6- Posting Images

Hello everyone,

For blog 6 you will need to post images. Please see the attached file as a tutorial for how to do this!

Good Luck!

Chem4101- Posting Images.pptx

BloG6 - Structures and Standards

Due October 26, 2011 before class.


October 19, 2011

Exam 2 - Examples



Please note that the topics tested in these sample exams are not necessarily the same as those covered in Exam 2 this year. For example, we will not have general questions about Infrared Spectroscopy or Electrochemistry this year.

Seminar - William Arnold - October 27, 2011

This presentation is part of the MinnMass Fall Meeting will be held October 27th at the St. Anthony Falls Laboratory in Minneapolis.

Tours of the facility: 5:00-6:30 PM

Presentation by Professor William Arnold at 7:00 PM.

Location: http://safl.umn.edu/contact


From triclosan to dioxins: How your handsoap leads to an unanticipated environmental problem. Triclosan is an antimicrobial chemical added to liquid handsoaps. After being washed down the drain, triclosan enters wastewater treatment plants where it is not completely removed. The triclosan (and related compounds) that is discharged into surface waters is transformed by sunlight into dioxins. Dioxins are persistent, bioaccumulative, toxic pollutants. Analysis of lake sediments demonstrates that dioxins arising from triclosan are accumulating in the environment.

October 17, 2011

Lecture 18 - Mass Spectrometry-I

Lecture notes of Wed Oct 19.

October 13, 2011

Lecture 17 - Atomic Absorption Spectrometry - II

These are the lecture notes for Monday October 17.


Lecture 16 - Atomic Absorption Spectrometry

These are the lecture notes for Friday October 14. Please note that I have corrected the lecture # in the slides (October 14, 10:36). Everything else is the same.


Office Hour Friday Change

Hello Everyone,

There will not be office hours tomorrow from 11-12.

If you would like to meet tomorrow, I will be available a vast majority of the afternoon. Please email me to make an appointment (sato0041@umn.edu).

I promise office hours will return to normal next Monday!


BloG5 - Fluorescence properties and measurements


Due Wednesday 19 before class.

October 11, 2011

Lecture 15 - Fluorescence, Part II


October 10, 2011

Blog 2 & 3 Grades

Hello everyone,

If you have completed blog entries 2 & 3, these posts have been entered.

As a reminder, I have office hours tomorrow from 11-12. Wise Owl Cafe.


BlOG4 - Studies needed to test hypothesis


Due October 17, 2011

October 8, 2011

Lecture 14 - Fluorescence


The lecture notes mention a paper by Lasser-Ross et al, J. Neurophysiol, 1992, 68, 1167. In the next exam, there may be bonus points based on the methods section of this paper. Read the paper if interested.

October 5, 2011

BlOG3 - Similar analytical problems

Please refer to the presentations given in class on October 5, 2011. Posting is due Friday October 7, 2011.


October 3, 2011

Exam 1 Notes


There was a comment posted concerning Exam 1 about what you can and cannot put onto your note crib sheet. Definitions are not allowed! You may list equations and what the variables represent. Constants may also be given.