Stefanie Mueller, Pedro Lopes, and Patrick Baudisch at Hasso Plattner Institute have created an "interactive drafting table" by allowing the user to draw directly onto an object with a hand held laser pointer. The laser pointers movements and gestures are captured by an overhead camera and translated into commands for the laser cutter, eliminating the need for a drafting program.
More detailed information on how the system works can be found here. But in short the overhead camera captures movement and gestures which are translated into previously configured commands that can be used to generate specific types of actions such as rounding corners, creating points, removing material, etc. The overall effect is a much freer way of working with the laser cutter that affords a more step by step iterative design process.