Publications

Heltemes-Harris LM, Willette MJ, Ramsey LB, Qiu YH, Neeley ES, Zhang N, Thomas DA, Koeuth T, Baechler EC, Kornblau SM, Farrar MA. Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia. J Exp Med. 2011 Jun 6;208(6):1135-49. PubMed PMID: 21606506.

Bilgic H, Ytterberg SR, Amin S, McNallan KT, Wilson JC, Koeuth T, Ellingson S,
Newman B, Bauer JW, Peterson EJ, Baechler EC, Reed AM. Interleukin-6 and type I
interferon-regulated genes and chemokines mark disease activity in dermatomyositis.
Arthritis Rheum. 2009 Nov;60(11):3436-46. PubMed PMID: 19877033.

Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X, Ortmann W, Kosoy R,
Ferreira RC, Nordmark G, Gunnarsson I, Svenungsson E, Padyukov L, Sturfelt G,
Jönsen A, Bengtsson AA, Rantapää-Dahlqvist S, Baechler EC, Brown EE, Alarcón GS,
Edberg JC, Ramsey-Goldman R, McGwin G Jr, Reveille JD, Vilá LM, Kimberly RP,
Manzi S, Petri MA, Lee A, Gregersen PK, Seldin MF, Rönnblom L, Criswell LA,
Syvänen AC, Behrens TW, Graham RR. A large-scale replication study identifies
TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus
erythematosus.
Nat Genet. 2009 Nov;41(11):1228-33. Epub 2009 Oct 18. PubMed PMID: 19838195; PubMed Central PMCID: PMC2925843.

Bauer JW, Petri M, Batliwalla FM, Koeuth T, Wilson J, Slattery C,
Panoskaltsis-Mortari A, Gregersen PK, Behrens TW, Baechler EC.
Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus
disease activity: a validation study
.
Arthritis Rheum. 2009 Oct;60(10):3098-107.
PubMed PMID: 19790071; PubMed Central PMCID: PMC2842939.

Petri M, Singh S, Tesfasyone H, Dedrick R, Fry K, Lal P, Williams G, Bauer J,
Gregersen P, Behrens T, Baechler E. Longitudinal expression of type I interferon
responsive genes in systemic lupus erythematosus
.
Lupus. 2009 Oct;18(11):980-9.
PubMed PMID: 19762399.

Bauer JW, Bilgic H, Baechler EC. Gene-expression profiling in rheumatic
disease: tools and therapeutic potential.
Nat Rev Rheumatol. 2009
May;5(5):257-65. Review. PubMed PMID: 19412192.

Emamian ES, Leon JM, Lessard CJ, Grandits M, Baechler EC, Gaffney PM, Segal B,
Rhodus NL, Moser KL. Peripheral blood gene expression profiling in Sjögren's
syndrome.
Genes Immun. 2009 Jun;10(4):285-96. Epub 2009 Apr 30. PubMed PMID:
19404300.

International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN),
Harley JB, Alarcón-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL,
Tsao BP, Vyse TJ, Langefeld CD, Nath SK, Guthridge JM, Cobb BL, Mirel DB, Marion
MC, Williams AH, Divers J, Wang W, Frank SG, Namjou B, Gabriel SB, Lee AT,
Gregersen PK, Behrens TW, Taylor KE, Fernando M, Zidovetzki R, Gaffney PM, Edberg
JC, Rioux JD, Ojwang JO, James JA, Merrill JT, Gilkeson GS, Seldin MF, Yin H,
Baechler EC, Li QZ, Wakeland EK, Bruner GR, Kaufman KM, Kelly JA. Genome-wide
association scan in women with systemic lupus erythematosus identifies
susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
.
Nat Genet. 2008
Feb;40(2):204-10. Epub 2008 Jan 20. PubMed PMID: 18204446.

Gaffney PM, Moser KL, Baechler EC. Defining a new molecular basis of systemic
lupus erythematosus through transcriptional profiling
.
Expert Rev Clin Immunol.
2007 Nov;3(6):913-23. PubMed PMID: 20477140.

Baechler EC, Bauer JW, Slattery CA, Ortmann WA, Espe KJ, Novitzke J, Ytterberg
SR, Gregersen PK, Behrens TW, Reed AM. An interferon signature in the peripheral
blood of dermatomyositis patients is associated with disease activity.
Mol Med.
2007 Jan-Feb;13(1-2):59-68. PubMed PMID: 17515957; PubMed Central PMCID:
PMC1869622.

Graham RR, Kyogoku C, Sigurdsson S, Vlasova IA, Davies LR, Baechler EC,
Plenge RM, Koeuth T, Ortmann WA, Hom G, Bauer JW, Gillett C, Burtt N, Cunninghame
Graham DS, Onofrio R, Petri M, Gunnarsson I, Svenungsson E, Rönnblom L, Nordmark
G, Gregersen PK, Moser K, Gaffney PM, Criswell LA, Vyse TJ, Syvänen AC, Bohjanen
PR, Daly MJ, Behrens TW, Altshuler D. Three functional variants of IFN regulatory
factor 5 (IRF5) define risk and protective haplotypes for human lupus.
Proc Natl
Acad Sci U S A. 2007 Apr 17;104(16):6758-63. Epub 2007 Apr 5. PubMed PMID:
17412832; PubMed Central PMCID: PMC1847749.

Bauer JW, Baechler EC, Petri M, Batliwalla FM, Crawford D, Ortmann WA, Espe
KJ, Li W, Patel DD, Gregersen PK, Behrens TW. Elevated serum levels of
interferon-regulated chemokines are biomarkers for active human systemic lupus
erythematosus.
PLoS Med. 2006 Dec;3(12):e491. PubMed PMID: 17177599; PubMed Central PMCID: PMC1702557.

Stoeckman AK, Baechler EC, Ortmann WA, Behrens TW, Michet CJ, Peterson EJ. A
distinct inflammatory gene expression profile in patients with psoriatic arthritis.
Genes Immun. 2006 Oct;7(7):583-91. Epub 2006 Sep 14. PubMed PMID:
16971957.

Graham RR, Kozyrev SV, Baechler EC, Reddy MV, Plenge RM, Bauer JW, Ortmann
WA, Koeuth T, González Escribano MF; Argentine and Spanish Collaborative Groups,
Pons-Estel B, Petri M, Daly M, Gregersen PK, Martín J, Altshuler D, Behrens TW,
Alarcón-Riquelme ME. A common haplotype of interferon regulatory factor 5 (IRF5)
regulates splicing and expression and is associated with increased risk of
systemic lupus erythematosus
.
Nat Genet. 2006 May;38(5):550-5. Epub 2006 Apr 16. PubMed PMID: 16642019.

Baechler EC, Batliwalla FM, Reed AM, Peterson EJ, Gaffney PM, Moser KL,
Gregersen PK, Behrens TW. Gene expression profiling in human autoimmunity.
Immunol Rev. 2006 Apr;210:120-37. Review. PubMed PMID: 16623768.

Batliwalla FM, Li W, Ritchlin CT, Xiao X, Brenner M, Laragione T, Shao T,
Durham R, Kemshetti S, Schwarz E, Coe R, Kern M, Baechler EC, Behrens TW,
Gregersen PK, Gulko PS. Microarray analyses of peripheral blood cells identifies
unique gene expression signature in psoriatic arthritis.
Mol Med. 2005
Jan-Dec;11(1-12):21-9. PubMed PMID: 16622521; PubMed Central PMCID: PMC1449519.

Behrens TW, Graham RR, Kyogoku C, Baechler EC, Ramos PS, Gillett C, Bauer J,
Ortmann WA, Hippen KL, Peterson E, Langefeld CD, Moser KL, Gaffney PM, Gregersen
PK. Progress towards understanding the genetic pathogenesis of systemic lupus
erythematosus
.
Novartis Found Symp. 2005;267:145-60; discussion 160-4. PubMed
PMID: 15999805.

Batliwalla FM, Baechler EC, Xiao X, Li W, Balasubramanian S, Khalili H, Damle
A, Ortmann WA, Perrone A, Kantor AB, Gulko PS, Kern M, Furie R, Behrens TW,
Gregersen PK. Peripheral blood gene expression profiling in rheumatoid arthritis.
Genes Immun. 2005 Aug;6(5):388-97. PubMed PMID: 15973463.

Baechler EC, Gregersen PK, Behrens TW. The emerging role of interferon in
human systemic lupus erythematosus.
Curr Opin Immunol. 2004 Dec;16(6):801-7.
Review. PubMed PMID: 15511676.

Kyogoku C, Langefeld CD, Ortmann WA, Lee A, Selby S, Carlton VE, Chang M,
Ramos P, Baechler EC, Batliwalla FM, Novitzke J, Williams AH, Gillett C, Rodine
P, Graham RR, Ardlie KG, Gaffney PM, Moser KL, Petri M, Begovich AB, Gregersen
PK, Behrens TW. Genetic association of the R620W polymorphism of protein tyrosine
phosphatase PTPN22 with human SLE.
Am J Hum Genet. 2004 Sep;75(3):504-7. Epub
2004 Jul 23. PubMed PMID: 15273934; PubMed Central PMCID: PMC1182029.

Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Moser K, Ortmann WA, Espe
KJ, Balasubramanian S, Hughes KM, Chan JP, Begovich A, Chang SY, Gregersen PK,
Behrens TW. Expression levels for many genes in human peripheral blood cells are
highly sensitive to ex vivo incubation
.
Genes Immun. 2004 Aug;5(5):347-53. PubMed
PMID: 15175644.

Moser KL, Gaffney PM, Grandits ME, Emamian ES, Machado DB, Baechler EC,
Rhodus NL, Behrens TW. The use of microarrays to study autoimmunity. J Investig
Dermatol Symp Proc. 2004 Jan;9(1):18-22. Review. PubMed PMID: 14870980.

Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ, Shark
KB, Grande WJ, Hughes KM, Kapur V, Gregersen PK, Behrens TW. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe
lupus.
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2610-5. Epub 2003 Feb 25.
PubMed PMID: 12604793; PubMed Central PMCID: PMC151388.

Graham RR, Ortmann WA, Langefeld CD, Jawaheer D, Selby SA, Rodine PR,
Baechler EC, Rohlf KE, Shark KB, Espe KJ, Green LE, Nair RP, Stuart PE, Elder JT,
King RA, Moser KL, Gaffney PM, Bugawan TL, Erlich HA, Rich SS, Gregersen PK,
Behrens TW. Visualizing human leukocyte antigen class II risk haplotypes in human
systemic lupus erythematosus.
Am J Hum Genet. 2002 Sep;71(3):543-53. Epub 2002
Jul 26. PubMed PMID: 12145745; PubMed Central PMCID: PMC379191.

Bannantine JP, Baechler E, Zhang Q, Li L, Kapur V. Genome scale comparison of
Mycobacterium avium subsp. paratuberculosis with Mycobacterium avium subsp. avium
reveals potential diagnostic sequences.
J Clin Microbiol. 2002 Apr;40(4):1303-10.
PubMed PMID: 11923349; PubMed Central PMCID: PMC140397.

Graham RR, Langefeld CD, Gaffney PM, Ortmann WA, Selby SA, Baechler EC, Shark KB, Ockenden TC, Rohlf KE, Moser KL, Brown WM, Gabriel SE, Messner RP, King RA, Horak P, Elder JT, Stuart PE, Rich SS, Behrens TW. Genetic linkage and
transmission disequilibrium of marker haplotypes at chromosome 1q41 in human
systemic lupus erythematosus.
Arthritis Res. 2001;3(5):299-305. Epub 2001 Jul 17. PubMed PMID: 11549371; PubMed Central PMCID: PMC64842.

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