Main

March 5, 2008

Almost 10 Years and Still Expanding

The International Space Station was put into orbit in November 1998 and has been continually added to since then. They recently posted photos of the station with new modules in place. (Via Astronomy Picture of the Day).

ISS Circa 2002
ISS2002.jpg

ISS Circa 2008
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Don't Buy Bottle Water

Not only do we have some of the strictest water standards in the united states, which bottled water makers do not need to adhere to, it also costs a lot more ecologically to produce all those stupid bottles. Go Glass!

February 29, 2008

Get Vaccinated!

Every winter you hear the same thing, "Get Vaccinated!" or as they say here at the University of Minnesota, "Do it for the herd!" Despite the fact they make humans into a pack of animals, this is exactly what we are. Packed into cities, apartment buildings, dorms and schools, there is real danger that a simple disease can be easily passed from person to person.
After growing up in the 1990's, me and my peers have never seen an epidemic that lead to mass deaths. The only thing I ever learned about was HIV, and despite the seriousness of this disease, it can only be passed through sexual contact and from bodily fluids. This characteristic of HIV makes it fairly easy to protect yourself against it.
The real threat to most people comes in the form of the flu and other diseases that can be passed on just by sneezing or being careless. We may not all have seen the effects of this, but the history books show what can happen. The 1918 Spanish Flu pandemic killed around 20 million people worldwide. Measles, a not so common disease which is becoming more common, is usually vaccinated for when a child reaches 18 months and can prove to be deadly. Unvaccinated populations in Nigeria have become at risk because they wouldn't vaccinate for religious and cultural reasons. The BBC reports that even in America and other Western Nations people are not vaccinating children because of the archaic myth that vaccinations increase the risk of Autism in children. This is absurd and with immunization could prevent 900 children under the age of nine from getting measles.
The possibility that immunization could aggravate underlying forms of autism is a dangerous myth that shouldn't even be a question any more. The vaccinations that were in question were made with thimerosal, and due to unfounded toxicity concerns have been discontinued and replaced by mercury-free mediums. The real danger is not whether a person will become autistic (I've had so many thimerosal shots I should be acting like the mad hatter if this were true) but whether that person will contract a potentially deadly illness and, even worse, pass it on.
So when living in a crowded place like a city, like a dorm, a house with multiple people, going to a busy school, or wherever you find yourself around a great number of people, don't just think of your personal well being, think of the other people. They could be carrying a virus, or could be susceptible to a virus. Get vaccinated. Do it for the herd.

January 31, 2008

Gene Expression as a Function of Diet

In my lab I work with a transcription factor called the Carbohydrate Response Element Binding Protein (ChREBP) that activates in a pathway that uses glucose as a signaling molecule to activate transcription of a certain set of genes. The signaling occurs after meals rich in carbohydrates, which are converted to simpler sugars such as glucose. This signaling can have a great effect on which proteins are being expressed at any point.
PLoS ONE has an article by Somel, Creely, et al that takes a look at how the diet difference between humans and other primates can effect differences in phenotype and genotype.

The effects of human diets were found to be significantly different from that of a chimpanzee diet in the mouse liver, but not in the brain. Importantly, 10% of the genes that differ in their expression between humans and chimpanzee livers differed also between the livers of mice fed the human and chimpanzee diets. Furthermore, both the promoter sequences and the amino acid sequences of these diet-related genes carry more differences between humans and chimpanzees than random genes. Our results suggest that the mouse can be used to study at least some aspects of human-specific traits.