The results of a hybrid Phas I/II clinical trial of the Nicotine Vaccine, the one I was working with before medical school, has just been reported in the journal Clinical Pharmacology & Therapeutics (2005:78(5);456-467):
Immunotherapy is a novel potential treatment for nicotine addiction. The aim of this study was to assess the safety and immunogenicity of a nicotine conjugate vaccine, NicVAX, and its effects on smoking behavior. Smokers (N = 68) were recruited for a noncessation treatment study and assigned to 1 of 3 doses of the nicotine vaccine (50, 100, or 200 microg) or placebo. They were injected on days 0, 28, 56, and 182 and monitored for a period of 38 weeks. Results showed that the nicotine vaccine was safe and well tolerated. Vaccine immunogenicity was dose-related (P < .001), with the highest dose eliciting antibody concentrations within the anticipated range of efficacy. There was no evidence of compensatory smoking or precipitation of nicotine withdrawal with the nicotine vaccine. The 30-day abstinence rate was significantly different across the 4 doses (P = .02), with the highest rate of abstinence occurring with 200 microg. The nicotine vaccine appears to be a promising medication for tobacco dependence.Posted by calv0016 at December 17, 2005 11:40 AM
I wish I could be part of the clinical trials. I have smoked for 40 years. I've tried the patch, the pills, the gum and even accupucture with no lasting results. I have to visit the lung doctor today, and that's always scarey.
Posted by: Diane Van Cleave at February 23, 2006 10:47 AMi too would like to be included in your trial studies, i really need to qiut smoking!!!!!!!!!
Posted by: Sonya at March 23, 2006 9:00 AMA friend of mine has a friend in Florida who received a shot to quit smoking. I do not know if it is this drug, but he has not smoked in 10 months. I too would like to be a part of these trials, my mother died of lung cancer(smoking) 26 years ago and my husband passed away 2yrs ago from lung cancer(agent orange & chemicals in viet nam) plus he also smoked the last 10yrs. Now I have a small spot on my lung, SO, I really need to QUIT. If anyone knows which University Hospitals the clincal trials are being held, please post them back on this site. Thanks, Good luck to all in their fight to be SMOKELESS
Posted by: Bonnie at July 17, 2006 8:54 PMA friend of mine has a friend in Florida who received a shot to quit smoking. I do not know if it is this drug, but he has not smoked in 10 months. I too would like to be a part of these trials, my mother died of lung cancer(smoking) 26 years ago and my husband passed away 2yrs ago from lung cancer(agent orange & chemicals in Viet Nam) plus he also smoked the last 10yrs. Now I have a small spot on my lung, SO, I really need to QUIT. If anyone knows which University Hospitals the clincal trials are being held, please post them back on this site. Thanks, Good luck to all in their fight to be SMOKELESS
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