In the tv series "New Girl," Zooey Deschanel plays Jess Day, a young, eccentric, and downright quirky teacher that has recently had her heart broken. She's vibrant and unique in every way and brings a whole new meaning to the word "roommate" when she moves into an apartment with three bachelors. According to the big five model, I would assume that Jess would score very high in openness to experience and extraversion, and probably fairly high in agreeableness as well. She would definitely score lower in conscientiousness and neuroticism.
Jess is lively and unconventional to say the least (which is why she'd score high in openness and extraversion), but she tries very hard to make things work with her roommates... maybe a little too hard. That's why I don't think she would score quite as high in agreeableness - she's sociable, but not exactly easy for the guys to live with. I wouldn't really call her careful or responsible, even though she is a teacher. She tends to let her desire to please others get in the way of everything. But she's very positive, even in the stickiest situations. Her moods are simply varying degrees of happiness; so she's not very conscientious or neurotic.
With this combination, the writers create quite an interesting character that's very entertaining to watch. They've sure got me hooked! If you haven't seen the show, I suggest you try it!