For Massachusetts Gov. Mitt Romney led former Pennsylvania Sen. Rick Santorum by a 47%-to-35% margin in the recent Illinois Republican primary, CNN reported.
Romney was set to win around 41 of the 54 Illinois delegates, leaving him with a total of 562, more than twice the number of Rick Santorum, in second with 249.
Santorum has been thriving in rural areas and those that consider themselves extremely conservative.
Both Santorum and Romney plan to campaign in Louisiana, Wisconsin, and North Carolina along with Texas Rep. Ron Paul and former House Speaker Newt Gingrich.
Illinois is a unique state in that voters vote once for their Republican candidate and once more for their delegate choices, according to the Huffington Post.
At a disadvantage, Santorum failed to qualify for the ballot in four of the state's 18 congressional delegates, the Chicago Tribune reported.
The number of delegates required to clinch the Republic presidential nomination is 1,144.