Drs. Elizabeth Amin, Derek Hook, Barry Finzel, and Michael A. Walters (co-PI) have received a $612,312 grant from the Minnesota Partnership for Biotechnology and Medical Genomics for the project "Identification and optimization of small molecular inhibitors of the histone acetyltransferase Rtt109: A novel approach to prevent fungal infection." Collaborators at the Mayo Clinic include Drs. Zhiguo Zhang (co-PI) and Andrew Limper. The primary goal of this work is to discover and characterize inhibitors of Rtt109 that could serve as novel anti-fungal therapeutic agents.