Frozen & Freeze-Dried Systems Publications

R.K. Cavatur and R. Suryanarayanan, Characterization of frozen aqueous solutions by low temperature X-ray powder diffractometry. Pharm. Res., 15,194-199 (1998).

R.K. Cavatur and R. Suryanarayanan, Characterization of phase transitions during freeze-drying by in situ X-ray powder diffractometry. Pharm. Dev. Tech., 3, 579-586 (1998).

A. Pyne and R. Suryanarayanan. Phase transitions of glycine in frozen aqueous solutions and during freeze-drying. Pharm. Res. 18, 1448-1454 (2001).

R.K. Cavatur, N.M. Vemuri, A. Pyne, Z. Chrzan, D. Toledo-Velasquez and R. Suryanarayanan, Crystallization behavior of mannitol in frozen aqueous solutions. Pharm. Res., 19, 894-900 (2002).

A. Pyne, R. Surana and R. Suryanarayanan. Crystallization of mannitol below Tg' during freeze-drying in binary and ternary aqueous systems. Pharm. Res., 19, 901-908 (2002).

A. Pyne and R. Suryanarayanan, The effect of additives on the crystallization of cefazolin sodium during freeze-drying. Pharm. Res., 20, 283-291 (2003).

C. Telang, L. Yu and R. Suryanarayanan, Effective inhibition of mannitol crystallization in frozen solutions by sodium chloride. Pharm. Res., 20, 660-667 (2003).

A. Pyne, K. Chatterjee and R. Suryanarayanan, Crystalline to amorphous transition of disodium hydrogen phosphate during primary drying. Pharm. Res., 20, 802-803 (2003).

A. Pyne, K. Chatterjee and R. Suryanarayanan, Solute crystallization in mannitol-glycine systems - implications on protein stabilization in freeze-dried formulations. J. Pharm. Sci., 92, 2272-2283 (2003).

A. Pyne, R. Surana and R. Suryanarayanan, Enthalpic relaxation in frozen aqueous trehalose solutions. Thermochimica Acta, 405, 225-234 (2003).

C. Telang and R. Suryanarayanan, Crystallization of cephalothin sodium during lyophilization from tert-butyl alcohol - water cosolvent system. Pharm. Res., 22, 153-160 (2005).

K. Chatterjee, E.Y. Shalaev and R. Suryanarayanan, Raffinose crystallization during freeze-drying and its impact on recovery of protein activity. Pharm. Res., 22, 303-309 (2005).

K. Chatterjee, E.Y. Shalaev and R. Suryanarayanan, Partially Crystalline Systems in Lyophilization: I. Use of Ternary State Diagrams to Determine Extent of Crystallization of Bulking Agent. J. Pharm. Sci., 94, 798-808 (2005).

K. Chatterjee, E.Y. Shalaev and R. Suryanarayanan, Partially Crystalline Systems in Lyophilization: II. Withstanding Collapse at High Primary Drying Temperatures and Impact on Protein Activity Recovery. J. Pharm. Sci., 94, 809-820 (2005).

R. Surana, A. Pyne, M. Rani and R. Suryanarayanan, Measurement of enthalpic relaxation by differential scanning calorimetry - effect of experimental conditions. Thermochimica Acta, 433, 173-182 (2005).

X. Liao, R. Krishnamurthy and R. Suryanarayanan, Influence of the active pharmaceutical ingredient concentration on the physical state of mannitol - implications in freeze-Drying. Pharm. Res., 22, 1978-1985 (2005).

R. Govindarajan, K. Chatterjee, L. Gatlin, R. Suryanarayanan and E.Y. Shalaev, Impact of freeze-drying on ionization of sulfonephthalein probe molecules in trehalose-citrate systems. J. Pharm. Sci., 95, 1498-1510 (2006).

D.B. Varshney, S. Kumar, E.Y. Shalaev, S.W. Kang., L. Gatlin and R. Suryanarayanan, Solute crystallization in frozen systems - use of synchrotron radiation to improve sensitivity. Pharm Res., 23, 2368-2374 (2006).

X. Liao, R. Krishnamurthy, R. Suryanarayanan, Influence of Processing Conditions on the Physical State of Mannitol-Implications in Freeze-Drying. Pharm. Res., 24, 370-376 (2007).

D.B. Varshney, S. Kumar, E.Y. Shalaev, P. Sundaramurthi, S.W. Kang, L.A. Gatlin, R. Suryanarayanan. Glycine Crystallization in Frozen and Freeze-dried Systems: Effect of pH and Buffer Concentration. Pharm. Res., 24, 593-604 (2007).

D.B. Varshney, P. Sundaramurthi, S. Kumar, E.Y. Shalaev, S.-W. Kang, L.A. Gatlin, R. Suryanarayanan, Phase transitions in frozen systems and during freeze-drying: quantification using synchrotron x-ray diffractometry. Pharm. Res., 26, 1596-1606 (2009).

E. Lu, S. Ewing, L.A. Gatlin, R. Suryanarayanan, E.Y. Shalaev, The effect of bulking agents on the chemical stability of acid-sensitive compounds in freeze-dried formulations: sucrose inversion study. J. Pharm. Sci, 98 (9), 3387-3396 (2009).

P. Chakravarty, R. Berendt, E. Munson, V. Young Jr., R. Govindarajan, R. Suryanarayanan, Insights into the dehydration behavior of thiamine hydrochloride (vitamin B1) hydrates: Part I, J. Pharm. Sci., 99 (2), 816-827 (2010).

P. Sundaramurthi, E. Shalaev, R. Suryanarayanan, "pH Swing" in frozen solutions-consequence of sequential crystallization of buffer components. J. Phys. Chem. Lett., 1 (1), 265-268 (2010).

P. Sundaramurthi, R. Suryanarayanan, Trehalose crystallization during freeze-drying: implications on lyoprotection. J. Phys. Chem. Lett., 1 (2), 510-514 (2010).

B. Bhatnagar, S. Martin, E. Shalaev, D. Teagarden, R. Suryanarayanan, Investigation of PEG crystallization in frozen PEG - Sucrose - Water Solutions. I. Characterization of the non-equilibrium behavior during freeze-thawing, J. Pharm. Sci., 99 (6), 2609-2619 (2010).

P. Sundaramurthi, E. Shalaev, R. Suryanarayanan, Calorimetric and Diffractometric Evidence for the Sequential Crystallization of Buffer Components and the Consequential pH Swing in Frozen Solutions, J. Phys. Chem. B, 114 (14), 4915-4923 (2010).

B. Bhatnagar, S. Martin, E. Shalaev, D. Teagarden, R. Suryanarayanan, Investigation of PEG crystallization in frozen PEG - Sucrose - Water Solutions. II. Characterization of the equilibrium behavior during freeze-thawing, J. Pharm. Sci., 99 (11), 4510-4524 (2010).

P. Sundaramurthi, T.W. Patapoff, R. Suryanarayanan, Crystallization of trehalose in frozen solutions and its phase behavior during drying, Pharm. Res., 27 (11), 2374-2383 (2010).

P. Sundaramurthi, R. Suryanarayanan, The effect of crystallizing and non-crystallizing cosolutes on succinate buffer crystallization and the consequent pH shift in frozen solutions, Pharm. Res., 28(2), 374-385 (2011).

P. Sundaramurthi, R. Suryanarayanan, Thermophysical properties of carboxylic and amino acid buffers at subzero temperatures: relevance to frozen state stabilization, J. Phys. Chem, 115(21), 7154-7164 (2011).

B.S. Bhatnagar, S.W.H. Martin, T.S. Hodge, T.K. Das, L. Joseph, D.L. Teagarden, E.Y. Shalaev, R. Suryanarayanan, Investigation of PEG crystallization in frozen and freeze-dried PEGylated recombinant human growth hormone-sucrose systems: implications on storage stability, J. Pharm. Sci., 100(8), 3062-3075 (2011).

P. Sundaramurthi, R. Suryanarayanan, Predicting the crystallization propensity of carboxylic acid buffers in frozen systems-relevance to freeze-drying, J. Pharm. Sci., 100(4), 1288-1293 (2011).

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