Pharmaceutical Excipients Publications

S. Rastogi, M. Zakrzewski and R. Suryanarayanan, Investigation of solid-state reactions using variable temperature X-ray powder diffractometry. I. Aspartame hemihydrate. Pharm. Res., 18, 267-273 (2001).

A. Pyne and R. Suryanarayanan. Phase transitions of glycine in frozen aqueous solutions and during freeze-drying. Pharm. Res. 18, 1448-1454 (2001).

R.K. Cavatur, N.M. Vemuri, A. Pyne, Z. Chrzan, D. Toledo-Velasquez and R. Suryanarayanan, Crystallization behavior of mannitol in frozen aqueous solutions. Pharm. Res., 19, 894-900 (2002).

A. Pyne, R. Surana and R. Suryanarayanan. Crystallization of mannitol below Tg' during freeze-drying in binary and ternary aqueous systemsPharm. Res., 19, 901-908 (2002).

C. Telang, L. Yu and R. Suryanarayanan, Effective inhibition of mannitol crystallization in frozen solutions by sodium chloride. Pharm. Res., 20, 660-667 (2003).

A. Pyne, K. Chatterjee and R. Suryanarayanan, Crystalline to amorphous transition of disodium hydrogen phosphate during primary drying. Pharm. Res., 20, 802-803 (2003).

A. Pyne, K. Chatterjee and R. Suryanarayanan, Solute crystallization in mannitol-glycine systems - implications on protein stabilization in freeze-dried formulations. J. Pharm. Sci., 92, 2272-2283 (2003).

C.E. Botez, P.W. Stephens, C. Nunes and R. Suryanarayanan, Crystal structure of D-mannitol. Powder Diffraction, 18, 214218 (2003).

R. Surana, L. Randall, A. Pyne, N. M. Vemuri and R. Suryanarayanan, Determination of glass transition temperature and in situ study of the plasticizing effect of water by inverse gas chromatography. Pharm. Res., 20, 1647-1654 (2003).

C. Telang, R. Suryanarayanan and L. Yu, Crystallization of D-mannitol in binary mixtures with NaCl: phase diagram and polymorphism. Pharm. Res., 20, 1939-1945 (2003).

A. Pyne, R. Surana and R. Suryanarayanan, Enthalpic relaxation in frozen aqueous trehalose solutions. Thermochimica Acta, 405, 225-234 (2003).

R. Surana, A. Pyne and R. Suryanarayanan, Effect of aging on the physical properties of amorphous trehalose. Pharm. Res., 21, 867-874 (2004).

J.D. Meyer, S.J. Bai, M. Rani, R. Suryanarayanan, R. Nayar, J.F. Carpenter and M.C. Manning, Infrared spectroscopic studies of protein formulations containing glycine. J. Pharm. Sci., 93, 1359-1366 (2004).

R. Surana, A. Pyne and R. Suryanarayanan, Effect of preparation method on physical properties of amorphous trehalose. Pharm. Res., 21, 1167-1172 (2004).

S.J. Bai, M. Rani, R. Suryanarayanan, J.F. Carpenter, R. Nayar and M.C. Manning, Quantification of glycine crystallinity by near-infrared INIR) spectroscopy. J. Pharm. Sci., 93, 2439-2447 (2004).

C. Nunes, R. Suryanarayanan, C.E. Botez, P.W. Stephens, Characterization and crystal structure of D-mannitol hemihydrate. J. Pharm. Sci., 93, 2800-2809 (2004).

K. Chatterjee, E.Y. Shalaev and R. Suryanarayanan, Raffinose crystallization during freeze-drying and its impact on recovery of protein activity. Pharm. Res., 22, 303-309 (2005).

K. Chatterjee, E.Y. Shalaev and R. Suryanarayanan, Partially Crystalline Systems in Lyophilization: I. Use of Ternary State Diagrams to Determine Extent of Crystallization of Bulking Agent. J. Pharm. Sci., 94, 798-808 (2005).

K. Chatterjee, E.Y. Shalaev and R. Suryanarayanan, Partially Crystalline Systems in Lyophilization: II. Withstanding Collapse at High Primary Drying Temperatures and Impact on Protein Activity Recovery. J. Pharm. Sci., 94, 809-820 (2005).

R. Surana, A. Pyne, M. Rani and R. Suryanarayanan, Measurement of enthalpic relaxation by differential scanning calorimetry - effect of experimental conditions. Thermochimica Acta, 433, 173-182 (2005).

C. Nunes, A. Mahendrasingam and R. Suryanarayanan, Quantification of crystallinity in substantially amorphous materials by synchrotron X-ray powder diffractometry. Pharm. Res., 22, 1942-1953 (2005).

X. Liao, R. Krishnamurthy and R. Suryanarayanan, Influence of the active pharmaceutical ingredient concentration on the physical state of mannitol - implications in freeze-Drying. Pharm. Res., 22, 1978-1985 (2005).

R. Govindarajan, K. Chatterjee, L. Gatlin, R. Suryanarayanan and E.Y. Shalaev, Impact of freeze-drying on ionization of sulfonephthalein probe molecules in trehalose-citrate systems. J. Pharm. Sci., 95, 1498-1510 (2006).

M. Rani, R. Govindarajan, R. Surana and R. Suryanarayanan, Structure in dehydrated trehalose dihydrate - evaluation of the concept of partial crystallinity. Pharm Res., 23, 2356-2367 (2006).

D.B. Varshney, S. Kumar, E.Y. Shalaev, S.W. Kang., L. Gatlin and R. Suryanarayanan, Solute crystallization in frozen systems - use of synchrotron radiation to improve sensitivity. Pharm Res., 23, 2368-2374 (2006).

R. Govindarajan, A.V. Zinchuk, B.C. Hancock, E.Y. Shalaev and R. Suryanarayanan, Ionization states in the microenvironment of solid dosage forms: Effect of formulation variables and processing. Pharm. Res., 23, 2454-2468 (2006).

X. Liao, R. Krishnamurthy, R. Suryanarayanan, Influence of Processing Conditions on the Physical State of Mannitol-Implications in Freeze-Drying. Pharm. Res., 24, 370-376 (2007).

D.B. Varshney, S. Kumar, E.Y. Shalaev, P. Sundaramurthi, S.W. Kang, L.A. Gatlin, R. Suryanarayanan. Glycine Crystallization in Frozen and Freeze-dried Systems: Effect of pH and Buffer Concentration. Pharm. Res., 24, 593-604 (2007).

K. Chatterjee, E.Y. Shalaev and R. Suryanarayanan and R. Govindarajan, Correlation between chemical reactivity and the Hammett acidity function in amorphous solids using inversion of sucrose as a model reaction. J. Pharm. Sci., 97, 274-286 (2008).

E. Lu, N. Rodriguez-Hornedo, R. Suryanarayanan, A rapid thermal method for cocrystal screening. Cryst. Eng. Comm., 10 (6), 665-668 (2008).

T. Miyazaki, K. Sivaprakasam, J. Tantry, R. Suryanarayanan, Physical characterization of dibasic calcium phosphate dihydrate and anhydrate. J. Pharm. Sci, 98 (3), 905-916 (2009).

I. Dranca, S. Bhattacharya, S. Vyazovkin, R. Suryanarayanan, Implications of global and local mobility in amorphous sucrose and as determined by Differential Scanning Calorimetry. Pharm. Res., 26, 1064-1072 (2009).

D.B. Varshney, P. Sundaramurthi, S. Kumar, E.Y. Shalaev, S.-W. Kang, L.A. Gatlin, R. Suryanarayanan, Phase transitions in frozen systems and during freeze-drying: quantification using synchrotron x-ray diffractometry. Pharm. Res., 26, 1596-1606 (2009).

P. Chakravarty, S. Bhardwaj, L. King, R. Suryanarayanan, Monitoring phase transformations in intact tablets of α,α- Trehalose by FT-Raman spectroscopy, AAPS PharmSciTech, 10, 1420-1426 (2009).

S. Bhattacharya, R. Suryanarayanan, Local mobility in amorphous pharmaceuticals - characterization and implications on stability. J. Pharm. Sci, 98 (9), 2935-2953 (2009).

E. Lu, S. Ewing, L.A. Gatlin, R. Suryanarayanan, E.Y. Shalaev, The effect of bulking agents on the chemical stability of acid-sensitive compounds in freeze-dried formulations: sucrose inversion study. J. Pharm. Sci, 98 (9), 3387-3396 (2009).

P. Sundaramurthi, E. Shalaev, R. Suryanarayanan, "pH Swing" in frozen solutions-consequence of sequential crystallization of buffer components. J. Phys. Chem. Lett., 1 (1), 265-268 (2010).

P. Sundaramurthi, R. Suryanarayanan, Trehalose crystallization during freeze-drying: implications on lyoprotection. J. Phys. Chem. Lett., 1 (2), 510-514 (2010).

B. Bhatnagar, S. Martin, E. Shalaev, D. Teagarden, R. Suryanarayanan, Investigation of PEG crystallization in frozen PEG - Sucrose - Water Solutions. I. Characterization of the non-equilibrium behavior during freeze-thawing, J. Pharm. Sci., 99 (6), 2609-2619 (2010).

P. Sundaramurthi, E. Shalaev, R. Suryanarayanan, Calorimetric and Diffractometric Evidence for the Sequential Crystallization of Buffer Components and the Consequential pH Swing in Frozen Solutions, J. Phys. Chem. B, 114 (14), 4915-4923 (2010).

A.M. Kaushal, V.R. Vangala, R. Suryanarayanan, Unusual effect of water vapor pressure on dehydration of dibasic calcium phosphate dihydrate, J. Pharm. Sci., 100(4), 1456-1466 (2011).

K. Arora, N. Tayade, R. Suryanarayanan,Unintended water mediated cocrystal formation in carbamazepine and aspirin tablets, Mol. Pharm., 8(3), 982-989 (2011).

S. Bhardwaj, R. Suryanarayanan, Use of Dielectric Spectroscopy To Monitor Molecular Mobility in Glassy and Supercooled Trehalose, J. Phys. Chem., 116(38), 11728-11736 (2012).

S. Bhardwaj, R. Suryanarayanan, Molecular Mobility as an Effective Predictor of the Physical Stability of Amorphous Trehalose, Mol. Pharm., 9(11), 3209-3217 (2012).

S. Bhardwaj, R. Suryanarayanan, Molecular mobility as a predictor of the water sorption by annealed amorphous trehalose, Pharm. Res., 30(3), 714-720 (2013).

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