Solid State Pharmaceuticals Publications

R. Suryanarayanan and A.G. Mitchell, The precipitation of calcium gluceptate from aqueous solutions. J. Pharm. Sci., 73, 78-82 (1984).

R. Suryanarayanan and A.G. Mitchell, Evaluation of two concepts of crystallinity using calcium gluceptate as a model compound. Int. J. Pharm., 24, 1-17 (1985).

A.G. Mitchell and R. Suryanarayanan, Solubility of calcium gluceptate and the preparation of calcium gluceptate injection USP. J. Parenteral Sci. Tech., 40, 48-51 (1986).

R. Suryanarayanan and A.G. Mitchell, Phase transitions of calcium gluceptate. Int. J. Pharm., 32, 213-221 (1986).

W.W.L. Young and R. Suryanarayanan, Kinetics of transition of anhydrous carbamazepine (C15H12N2O) to carbamazepine dihydrate in aqueous suspensions. J. Pharm. Sci., 89, 496-500 (1991).

A.K. Dash and R. Suryanarayanan, Solid-state properties of tobramycin. Pharm. Res., 8, 1159-1165 (1991).

J. Han and R. Suryanarayanan, Applications of pressure differential scanning calorimetry in the study of pharmaceutical hydrates. 1. Carbamazepine dihydrate. Int. J. Pharm., 157, 209-218 (1997).

N.V. Phadnis and R. Suryanarayanan, Polymorphism in anhydrous theophylline - implications on the dissolution rate of theophylline tablets. J. Pharm. Sci., 86, 1256-1263 (1997).

J. Han, S. Gupte and R. Suryanarayanan, Applications of pressure differential scanning calorimetry in the study of pharmaceutical hydrates. 2. Ampicillin trihydrate. Int. J. Pharm., 170, 63-72 (1998).

J. Han and R. Suryanarayanan, Influence of environmental conditions on the kinetics and mechanism of dehydration of carbamazepine dihydrate. Pharm. Dev. Tech., 3, 587-596 (1998).

J. Han and R. Suryanarayanan, A Method for the Rapid Evaluation of the Physical Stability of Pharmaceutical Hydrates, Thermochimica Acta, 329, 163-170 (1999).

S. Rastogi, I. Zamansky, S. Roy, P. Tyle and R. Suryanarayanan, Solid-state phase transitions of AG337, an antitumor agent. Pharm. Dev. Tech., 4, 623-632 (1999).

R. Surana and R. Suryanarayanan, Quantification of crystallinity in substantially amorphous pharmaceuticals and study of crystallization kinetics by XRD, Powder Diffraction, 15, 2-6 (2000).

Y. Li, J. Han, G.G.Z. Zhang, D.J.W. Grant and R. Suryanarayanan, In situ dehydration of carbamazepine dihydrate - a novel technique to prepare amorphous anhydrous carbamazepine. Pharm. Dev. Tech., 5, 257-266 (2000).

S. Rastogi, M. Zakrzewski and R. Suryanarayanan, Investigation of solid-state reactions using variable temperature X-ray powder diffractometry. I. Aspartame hemihydrate. Pharm. Res., 18, 267-273 (2001).

A. Pyne, K. Chatterjee and R. Suryanarayanan, Crystalline to amorphous transition of disodium hydrogen phosphate during primary drying. Pharm. Res., 20, 802-803 (2003).

G.G.Z. Zhang, S.Y.L. Paspal, R. Suryanarayanan, D.J.W. Grant, Racemic species of sodium ibuprofen: Characterization and polymorphic relationships. J. Pharm. Sci., 92, 1356-1366 (2003).

C.E. Botez, P.W. Stephens, C. Nunes and R. Suryanarayanan, Crystal structure of delta-D-mannitol. Powder Diffraction, 18, 214218 (2003).

C. Telang, R. Suryanarayanan and L. Yu, Crystallization of D-mannitol in binary mixtures with NaCl: phase diagram and polymorphism. Pharm. Res., 20, 1939-1945 (2003).

R. Surana, A. Pyne and R. Suryanarayanan, Solid-vapor interactions: Influence of environmental conditions on the dehydration of carbamazepine dehydrate. AAPS Pharm.Sci.Tech. 4, Article 68, (2003).

S.J. Bai, M. Rani, R. Suryanarayanan, J.F. Carpenter, R. Nayar and M.C. Manning, Quantification of glycine crystallinity by near-infrared INIR) spectroscopy. J. Pharm. Sci., 93, 2439-2447 (2004).

C. Nunes, R. Suryanarayanan, C.E. Botez, P.W. Stephens, Characterization and crystal structure of D-mannitol hemihydrate. J. Pharm. Sci., 93, 2800-2809 (2004).

K. Chatterjee, E.Y. Shalaev and R. Suryanarayanan, Raffinose crystallization during freeze-drying and its impact on recovery of protein activity. Pharm. Res., 22, 303-309 (2005).

K. Chatterjee, E.Y. Shalaev and R. Suryanarayanan, Partially Crystalline Systems in Lyophilization: I. Use of Ternary State Diagrams to Determine Extent of Crystallization of Bulking Agent. J. Pharm. Sci., 94, 798-808 (2005).

K. Chatterjee, E.Y. Shalaev and R. Suryanarayanan, Partially Crystalline Systems in Lyophilization: II. Withstanding Collapse at High Primary Drying Temperatures and Impact on Protein Activity Recovery. J. Pharm. Sci., 94, 809-820 (2005).

X. Liao, R. Krishnamurthy and R. Suryanarayanan, Influence of the active pharmaceutical ingredient concentration on the physical state of mannitol - implications in freeze-drying. Pharm. Res., 22, 1978-1985 (2005).

M. Rani, R. Govindarajan, R. Surana and R. Suryanarayanan, Structure in dehydrated trehalose dihydrate - evaluation of the concept of partial crystallinity. Pharm Res., 23, 2356-2367 (2006).

C. Nunes, A. Mahendrasingam and R. Suryanarayanan, Investigation of the multi-step dehydration reaction of theophylline monohydrate using 2-dimensionsal powder X-ray diffractometry. Pharm. Res., 23, 2393-2404 (2006).

R. Govindarajan, A.V. Zinchuk, B.C. Hancock, E.Y. Shalaev and R. Suryanarayanan, Ionization states in the microenvironment of solid dosage forms: Effect of formulation variables and processing. Pharm. Res., 23, 2454-2468 (2006).

X. Liao, R. Krishnamurthy, R. Suryanarayanan, Influence of Processing Conditions on the Physical State of Mannitol-Implications in Freeze-Drying. Pharm. Res., 24, 370-376 (2007).

D.B. Varshney, S. Kumar, E.Y. Shalaev, P. Sundaramurthi, S.W. Kang, L.A. Gatlin, R. Suryanarayanan. Glycine Crystallization in Frozen and Freeze-dried Systems: Effect of pH and Buffer Concentration. Pharm. Res., 24, 593-604 (2007).

J.S. Tantry, J. Tank, R. Suryanarayanan, Processing-induced phase transitions of theophylline-implications on the dissolution of theophylline tablets. J. Pharm. Sci., 96, 1434-1444 (2007).


H. Yamada, R. Suryanarayanan, X-ray powder diffractometry of intact film coated tablets - an approach to monitor the physical form of the active pharmaceutical ingredient during processing and storage. J. Pharm. Sci., 96, 2029-2036 (2007).

K. Chatterjee, E.Y. Shalaev and R. Suryanarayanan and R. Govindarajan, Correlation between chemical reactivity and the Hammett acidity function in amorphous solids using inversion of sucrose as a model reaction. J. Pharm. Sci., 97, 274-286 (2008).

E. Lu, N. Rodriguez-Hornedo, R. Suryanarayanan, A rapid thermal method for cocrystal screening. Cryst. Eng. Comm., 10 (6), 665-668 (2008).

T. Miyazaki, K. Sivaprakasam, J. Tantry, R. Suryanarayanan, Physical characterization of dibasic calcium phosphate dihydrate and anhydrate. J. Pharm. Sci, 98 (3), 905-916 (2009).

D.B. Varshney, J.A. Elliott, L.A. Gatlin, S. Kumar, R. Suryanarayanan, E.Y. Shalaev, Synchrotron X-ray diffraction investigation of the anomalous behavior of ice during freezing of aqueous systems. J. Phys. Chem. B, 113 (18), 6177-6182 (2009).

P. Chakravarty, S. Bhardwaj, L. King, R. Suryanarayanan, Monitoring phase transformations in intact tablets of Trehalose by FT-Raman spectroscopy, AAPS Pharm.Sci.Tech., 10, 1420-1426 (2009).

S. Bhattacharya, R. Suryanarayanan, Local mobility in amorphous pharmaceuticals - characterization and implications on stability. J. Pharm. Sci, 98 (9), 2935-2953 (2009).

E. Lu, S. Ewing, L.A. Gatlin, R. Suryanarayanan, E.Y. Shalaev, The effect of bulking agents on the chemical stability of acid-sensitive compounds in freeze-dried formulations: sucrose inversion study. J. Pharm. Sci, 98 (9), 3387-3396 (2009).

P. Chakravarty, R. Berendt, E. Munson, V. Young Jr., R. Govindarajan, R. Suryanarayanan, Insights into the dehydration behavior of thiamine hydrochloride (vitamin B1) hydrates: Part I, J. Pharm. Sci., 99 (2), 816-827 (2010).

P. Chakravarty, R. Berendt, E. Munson, V. Young Jr., R. Govindarajan, R. Suryanarayanan, Insights into the dehydration behavior of thiamine hydrochloride (vitamin B1) hydrates: Part II, J. Pharm. Sci., 99 (4), 1882-1895 (2010).

P. Chakravarty, R. Berendt, E. Munson, V. Young Jr., R. Govindarajan, R. Suryanarayanan, Insights into the dehydration behavior of thiamine hydrochloride (vitamin B1) hydrates: Part II, J. Pharm. Sci., 99 (4), 1882-1895 (2010).

B. Bhatnagar, S. Martin, E. Shalaev, D. Teagarden, R. Suryanarayanan, Investigation of PEG crystallization in frozen PEG - Sucrose - Water Solutions. I. Characterization of the non-equilibrium behavior during freeze-thawing, J. Pharm. Sci., 99 (6), 2609-2619 (2010).

B. Bhatnagar, S. Martin, E. Shalaev, D. Teagarden, R. Suryanarayanan, Investigation of PEG crystallization in frozen PEG sucrose-water solutions: II. Characterization of the equilibrium behavior during freeze-thawing. J. Pharm. Sci. 99 (11), 4510-4524 (2010).

A.M. Kaushal, V.R. Vangala, R. Suryanarayanan, Unusual effect of water vapor pressure on dehydration of dibasic calcium phosphate dihydrate, J. Pharm. Sci., 100(4), 1456-1466 (2011).

K. Arora, N. Tayade, R. Suryanarayanan, Unintended water mediated cocrystal formation in carbamazepine and aspirin tablets, Mol. Pharm., 8(3), 982-989 (2011).

Z. Zong, S. Desai, A. Kaushal, D. Barich, H-S Huang, E. Munson, R. Suryanarayanan, L. Kirsch, The stabilizing effect of moisture on the solid-state degradation of gabapentin, The stabilizing effect of moisture on the solid-state degradation of gabapentin, AAPS Pharm. Sci. Tech., 12(3), 924-931 (2011).

S. Bhattacharya, R. Suryanarayanan, Molecular motions in sucrose-PVP and sucrose-sorbitol dispersions: I. Implications of global and local mobility on stability, Pharm. Res., 28(9), 2191-2203 (2011).

P. Chakravarty, R. Suryanarayanan, R. Govindarajan, Phase transformation in thiamine hydrochloride tablets: Influence on tablet microstructure, physical properties, and performance, J. Pharm. Sci., 101(4), 1410-1422 (2012).

P. Sundaramurthi, M. Burcusa, R. Suryanarayanan, Physical characterization of pentamidine isethionate during freeze-drying-relevance to development of stable lyophilized product, J. Pharm. Sci., 101(5), 1732-1743 (2012).

S. Bhardwaj, K. Arora, E. Kwong, A. Templeton, A.-D. Clas, R. Suryanarayanan, Correlation between molecular mobility and physical stability of amorphous itraconazole, Mol. Pharm., 10(2), 694-700 (2013).

K. Arora, S. Thakral, R. Suryanarayanan, Instability in theophylline and carbamazepine hydrate tablets: cocrystal formation due to release of lattice water, Pharm. Res., 30(7), 1779-1789 (2013).

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