The Clinical and Translational Science Institute (CTSI) announced 10 new scholars will join its Translational Research Development Program (TRDP), which gives early-stage investigators an opportunity to gain experience in clinical and translational research.

The program, formerly known as the F&T Trainee Program, provides postdoctoral and predoctoral trainees with a mentoring team and up to $16,000 in research funds to help advance their research.

Congratulations to our newest TRDP scholars:

Jeff Flynn, PhD, Department of Microbiology
Project title: Anaerobic bacterial consortia sustain the growth of pathogens in the upper airways of cystic fibrosis patients
Primary mentor: Ryan Hunter, PhD
TRDP mentor: Jordan Dunitz, MD

Diego Garcia-Huidobro, MD, Department of Pediatrics
Project title: Feasibility of a One-To-One Parenting Intervention to Prevent Substance Use in Latino Youth
Primary mentor: Michele Allen, MD, MS
TRDP mentor: Iris Borowsky, MD, PhD

Rachel Hardeman, PhD, Department of Medicine
Project title: Racial/Ethnic Disparities in Birth Outcomes: Examining the Role of the Patient/Provider Relationship
Primary mentor: Diana Burgess, PhD
TRDP mentor: Katy Kozhimannil, PhD, MPA

Christopher Janson, MD, Department of Neurology
Project title: High-Throughput Discovery with Unique Alzheimer's Cellular Model
Primary mentor: Cornelius Lam, MD, PhD
TRDP mentor: Gunda Georg, PhD

Sakeen Kashem, BA, Department of Dermatology
Project title: Langerhans cell function in controlling fungal immunity and commensalism
Primary mentor: Daniel Kaplan, MD, PhD
TRDP mentor: Maria Hordinksy, MD

Liliane Mukaremera, PhD, Department of Microbiology
Project title: Alteration of the innate immune response by different Cryptococcus neoformans morphologies in HIV and healthy individuals
Primary mentor: Kirsten Nielsen, PhD
TRDP mentor: David Boulware, MD, MPH

Justin Ryder, PhD, Department of Epidemiology
Project title: Longitudinal assessment of novel biomarkers for predicting cardiovascular disease in youth
Primary mentor: Aaron S. Kelly, PhD
TRDP mentor: Kyle Rudser, PhD

Elizabeth Thompson
, MS, College of Biological Sciences
Project title: Gene therapy for Fanconi anemia using Cas9/CRISPR-mediated gene targeting
Primary mentor: Eric A. Hendrickson, PhD
TRDP mentor: Jakub Tolar, MD, PhD

Diana Wallin, BS, Department of Neuroscience
Project title: The effect of recombinant human erythropoietin (RhEpo) therapy on the hippocampus of anemic neonatal mice
Primary mentor: Michael K. Georgieff, MD
TRDP mentor: Gregory Vercellotti, MD

Andrea Wolf, BS, Department of Surgery
Project title: Formulation Optimization of a Low-Volume Resuscitation Fluid for Hemorrhagic Shock
Primary mentor: Greg Beilman, MD
TRDP mentor: Raj Suryanarayanan, PhD

CTSI Poster Session 2014The Clinical and Translational Science Institute (CTSI) recognized 12 researchers for having outstanding posters and presentations at the third annual CTSI Poster Session & Reception held on September 15. More than 150 people attended the event, including a group of Shattuck-St. Mary's students who are working closely with the poster presenters on a class project.

Judges evaluated more than 50 posters, and selected winners from each CTSI career development program as well as from the Community Collaborative grants program. CTSI will provide as much as $17,500 total in travel expenses so awardees can present their CTSI-supported research at a national or international conference.

Please join us in congratulating the 2014 travel award recipients!

Undergraduate Research Program (URP)
Samantha Carlson, School of Public Health
Stephanie Duong, Macalester College

Advanced Research Program (ARP)
David Matson, Medical School
Benjamin Otopalik, Medical School
Kinjal Sanghavi, College of Pharmacy

Translational Research Development Program (TRDP)
Alexa Weingarden, Medical School

New Investigator Pre-K Career Development Program
Stephanie Misono, Department of Otolaryngology, Medical School

KL2 Scholars Career Development Program
Ann Parr, Neurosurgery Department, Medical School
Guisheng Song, Department of Medicine, Medical School

K to R01 Transition to Independence Program

Melena Bellin, Department of Pediatrics, Medical School

R to R Pilot Grant
Robert Jones, Department of Development and Surgical Sciences, School of Dentistry

Community Collaborative grants program
Patricia Shannon, School of Social Work, College of Education and Human Development

2014 Mentor of the Year AwardLast evening at the CTSI Poster Session and Reception, CTSI recognized Kelvin O. Lim, MD, with the third annual Mentor of the Year Award, as well as Alicia Allen, PhD, with the Outstanding Junior Mentor Award, a new award that recognizes mentors with the rank of assistant professor. Both awards recognize outstanding research mentors, using nominations provided by the mentees themselves and faculty colleagues.

Mentor of the Year: Dr. Kelvin Lim
Dr. Lim serves as a professor of the Department of Psychiatry at the University of Minnesota Medical School. His research focuses on applying advanced neuroimaging methods to the study of neuropsychiatric disorders.

Several individuals wrote letters in support of Dr. Lim's qualifications for the award, praising him for his enthusiasm, passion, dedication, and integrity. Following is an excerpt from one of these letters:

"His talents transcend departmental lines and he brings together collaborations within the University and internationally with a high level of enthusiasm and skill. His international reputation, his extensive network of collaborators, his ability to attract talented individuals, and his well-respected research programs all serve the University of Minnesota extremely well, especially in regard to the training and mentoring of young scientists."

Dr. Lim received $1,500 for this recognition, and accepted the award from Dr. Jasjit Ahluwalia (shown, with Dr. Lim), Associate Director of CTSI who leads CTSI-Ed, CTSI's Research Education, Training, and Career Development function.

Outstanding Junior Mentor: Alicia Allen

Dr. Allen is an assistant professor in the Department of Family Medicine and Community Health at the University of Minnesota. Her current research focuses on how sex hormones influence smoking behavior and smoking cessation outcomes.

Letters in support of Dr. Allen commended her for being kind, approachable, caring, and genuinely interested in helping mentees be more successful. Following are excerpts from these letters:

"Not only does Alicia care about her mentee's scientific progress and success, but she also cares about her mentees as individuals. Alicia wants only the best for her students, in and outside the office. She was always interested in my future career and academic development."

"She is approachable and available, has excellent communication and guidance, and motivates me to learn. She gives me the confidence and tools to step outside of my comfort zone, be independent, and experience clinical research."

Dr. Allen was awarded $500 for this honor.

Join us in congratulating Drs. Lim and Allen!

Researchers now have a simpler, more effective way to access data from Minnesota death certificate records, with the launch of a new database from the Clinical and Translational Science Institute (CTSI). CTSI will fulfill requests for death certificate record data at no charge to researchers, registries, and transplant databases at the University of Minnesota and Fairview.

The database houses the complete death record issued from 2011 to present (for deaths as recent as two months ago) for deceased individuals who were born in Minnesota, have died in Minnesota, or have ever had a permanent address in the state. CTSI collaborated with the Minnesota Department of Health to create this database, and tested it against University health data repositories to validate accuracy and help maximize its value to investigators.

"Historically, getting access to death records took a lot of time, money, and resources. Plus, it wasn't uncommon for the data itself to be incomplete or outdated, as databases would sometimes exclude records from the past few years," says Russell Luepker, MD, MS, a member of CTSI's Biomedical Informatics steering committee. "Now, researchers can quickly access up-to-date, accurate death data, with the support of dedicated informatics experts - all at no cost to them."

Researchers request this data simply by filling out an online form, which CTSI uses to generate a customized, cleaned-up dataset that's tailored to an investigator's needs. For example, a researcher could request data only from the death records, which does not require IRB approval. Or, to get a more complete picture, they could request a dataset that combines data from both death records and patient records. Patient data is extracted from CTSI's clinical data repository, which houses the electronic medical records of more than 2 million patients and can be leveraged by University and Fairview researchers at no cost to them.

"Understanding who died, and why is critical to researchers who are looking for better ways to prevent, diagnose, and treat health issues," says Bonnie Westra, PhD, RN, Co-chair of CTSI's Architecture and Informatics Committee. "The information provided by death certificate records is valuable to a wide range of research studies, and can be used in a variety of ways, from better understanding health issues to more sensitively recruiting prior patients to join studies without the risk of contacting the families of deceased individuals."

Minnesota death certificates include demographic data, such as an individual's name, gender, social security number, birth date, and date of death, as well as data about the circumstances of their death, such as the cause, site, and any external causes revealed by an autopsy.

Learn more about accessing data for research.

UMN CTSI Research Toolkit.jpgUniversity of Minnesota investigators and their teams have a simpler way to find the resources they need to conduct research, with the launch of the Research Toolkit on the Clinical and Translational Science Institute's (CTSI) enhanced website.

The new online resource houses research tools, templates, information, and guidance developed by a wide range of sources, from University organizations to federal agencies. The Clinical and Translational Science Institute spearheaded and manages the Research Toolkit, and worked with subject matter experts from across the Academic Health Center to curate content.

"We created the Research Toolkit to give health researchers a simpler way to navigate the University research process, and ultimately advance their discoveries," says Connie Delaney, PhD, RN, FAAN, FACMI, who directs CTSI's Biomedical Informatics function and oversees the Research Toolkit. "This supports CTSI's overarching efforts to create an integrated home for clinical and translational research, and help researchers be more successful."

Users can find what they're looking for by navigating the Research Toolkit's chronological study steps, each of which contains information about the various components of that step in the research process:

  • Get started: Background research, clinical data access, finding collaborators, protocol development, and study feasibility
  • Apply for funding: Funding opportunities, grant writing and submissions, and cost estimates
  • Set up study: Budgeting, building your research team, IRB approvals, regulations, and recruiting research subjects
  • Conduct study: Budget management, billing, ethics, and compliance
  • Close out study: Closeout tasks, manuscript development, publishing, promotions, and dissemination

In addition, users can locate resources via the Research Toolkit's search function or by contacting CTSI's Research Navigator at ctsi@umn.edu or 612.625.CTSI (2874).

"As CTSI's Research Navigator, I am committed to connecting investigators and their teams with expertise, services, and resources that can support their research," says Melissa Hansen, one of the key leads of the Research Toolkit initiative. "With the Research Toolkit, they have another option for finding what they need, when they need it."