May 2012 Archives

By receiving the Clinical and Translational Science Award, the University of Minnesota is now required by the NIH to ensure an acknowledgment of the CTSA in any publications that result from UMN CTSI assistance with a project. This language was recently updated when the CTSA program was transferred from the National Center for Research Resources (NCRR) to the new National Center for Advancing Translational Sciences (NCATS) at the NIH.

When to acknowledge CTSA support
Please note that assistance is not limited to monetary support (e.g., pilot grant funds), but also includes use of CTSI space, consultation with CTSI faculty or staff, and use of any CTSI Internal Service Organization services (Project Management, Clinical Research Coordinators, Nursing and Nutritional Services, Biostatistical support, and Regulatory assistance such as IND/IDE support, clinical trial monitoring, or ClinicalTrials.gov support).

How to acknowledge CTSA support
All publications resulting from the use of CTSI resources are required to credit CTSA by using the text below.

"This publication [or project] was supported by Grant Number 1UL1RR033183 from the National Center for Research Resources (NCRR) and by Grant Number 8 UL1 TR000114-02 from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) to the University of Minnesota Clinical and Translational Science Institute (CTSI). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the CTSI or the NIH. The University of Minnesota CTSI is part of a national Clinical and Translational Science Award (CTSA) consortium created to accelerate laboratory discoveries into treatments for patients."

The CTSI F & T Pilot Grant Program is for predoctoral and NIH fellowship trainees, and includes up to $16,000 in pilot funds for clinical and translational projects and mentoring. Please join us in congratulating these accomplished trainees!

Daniel Beisang, BS, Medical School
Primary Mentor: Marc Jenkins, PhD
Subproject Mentor: Michael Georgieff, MD
Project Title: Quantitative Assessment of the Diversity of the Neonatal T cell Repertoire

Jose Debes, MD, Medical School
Primary Mentor: Paul Bohjanen, MD, PhD
Subproject Mentor: John Lake, MD
Project Title: Expression of the Hepatitis C Protein NS5A and Its Target Transcripts in Human Liver

Caroline Diep, BA, BS, Medical School
Primary Mentor: Carol Lange, PhD
Subproject Mentor: Peter Argenta, MD
Project Title: Ex vivo Modeling of Primary Ovarian Cancer Cells in 3D Culture Systems

Anne Frosch, MD, Medical School
Primary Mentor: Chandy John, MD, MS
Subproject Mentor: George Ayodo
Project Title: The Effect of HIV Infection on Malaria Specific B cell Subset Frequency

David Knorr, BS, Medical School
Primary Mentor: Michael Verneris, MD
Subproject Mentor: Todd DeFor, MS
Project Title: Evaluation of the CD4+ T cell Response against Influenza following Hematopoietic Cell Transplantation

Jessica Musselman, MS, School of Public Health
Primary Mentor: Jenny Poynter, PhD
Subproject Mentor: Julie Ross, PhD
Project Title: Methylation of the BMP/TGFβ Pathway and Correlation with Survival in Childhood Germ Cell Tumors

Ryan Nelson, BA, Medical School
Primary Mentor: Marc Jenkins, PhD
Subproject Mentor: Marshall Hertz, MD
Project Title: CD4+ T cell Responses toward Minor Y antigens following Male to Female Lung Transplant

Brent Sorenson, School of Dentistry
Primary Mentor: Mark Herzberg, DDS, PhD
Subproject Mentor: Rajaram Gopalakrishnan, DDS
Project Title: Tumor-targeted Reduction of Hyopxia-inducible Factor in Oral Carcinoma by Calprotectin

The Clinical and Translational Science Institute (CTSI) and the Center for Health Equity (CHE) are pleased to announce the 2012 Summer Undergraduate and Advanced Research Program awardees. Please join us in congratulating them!

Advanced Research Program Scholars
The Advanced Research Program is open to University of Minnesota health sciences professional students with an interest in clinical and translational science research. The program provides research training through a structured core curriculum, mentored research projects, weekly research seminars, and a final mini-symposium to present research to other scholars and mentors.

Elizabeth Aby, Medical School
Mentor: Jerrold Vitek, MD
Clinical Assessment of the Reliability and Feasibility of ParkinTune in Deep Brain Stimulation (DBS) Programming

Suresh Kumar Agarwal, College of Pharmacy
Mentor: James Cloyd, PharmD
A Meta-Analysis of the Absorption Characteristics of Diazepam Following Alternative Routes of Administration for Acute Repetitive Seizures

Krista Johnson, College of Pharmacy
Mentor: James Cloyd, PharmD
A study comparing blood and plasma assay methods for measurement of topiramate concentrations

Susan Lee, Medical School
Mentor: Ruby Nguyen, PhD
Comparing Diagnostics of OB Ultrasounds in Obese Minority Women

Craig Meyer, School of Public Health
Mentor: Pamela Schreiner, PhD, MS
Self-reported depression and discrimination and brain tissue volume

Sarah Parker, Medical School
Mentor: Bruce Blazar, MD
Characterization of Distinct iPS Cells for Potential Therapy in Hurler Syndrome

LeeAnna Pederson, College of Pharmacy
Mentor: Robert Straka, PharmD
Consideration of Genetic Variations of UGT2B7 and APOE Genes Within the Pharmacogenomics for Hypertriglyceridemia in Hispanics Trial

Gina Piscitello, Medical School
Mentor: Susan Everson-Rose, PhD, MPH
How psychosocial stressors such as hostility, anxiety, anger, discrimination, and depression differ in the way they affect progression of paw and adiposity in African-American women versus non-Hispanic Caucasian women

Casey Sautter, Medical School
Mentor: Chandy John
Health Problems of International Adoptees

Faduma Sharif, Medical School
Mentor: Kola Okuyemi, MD, MPH
Factors that Contributed to High Retention Rate in Quit Smoking Study in Homeless Population


Undergraduate Research Program Scholars

The Undergraduate Research Program provides promising students from populations under-represented in research with knowledge, skills, and experience in health care research. This summer program includes research training through a structured core curriculum, closely supervised research projects, and clinical research seminars.

Co Duong, College of Biological Sciences
Mentor: ?Susan Everson-Rose, PhD, MPH

Nima Odowa, College of Liberal Arts
Mentor: Naty Lopez?, PhD, MEd

Kendra Radtke, College of Biological Sciences
Mentor: James Cloyd?, PharmD

Uyen Truong, College of Science and Engineering
Mentor: Brian Van Ness, PhD

Sara Cronquist, College of Liberal Arts
Mentor: Janet Thomas?, PhD

Anthony Osifuye, College of Liberal Arts
Mentor: Kathleen Call?, PhD

Danielle Swichtenberg, College of Biological Sciences
Mentor: Carol Peterson?, PhD

John Tarnowski, College of Biological Sciences
Mentor: Julie Ross, PhD

Meet Sandra Wells, ODAT Project Manager. Sandra joined CTSI in January 2012.

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Need help? Contact Sandra directly at (612) 625-3073 or smwells@umn.edu.

Why do you work in clinical and translational research?

The translation of basic research findings into clinical studies is one of the greatest challenges of developing new therapeutics, diagnostics and treatment strategies for patients. Having worked in both academia and the biotech/pharmaceutical industry, I've developed an appreciation for the value of team science, and believe that academia can play a critical role in the early translational process. I'm excited for the opportunity to work in the CTSI, and look forward to contributing to the development of programs and partnerships to more effectively bridge the gap between basic and clinical research at UMN.

What does your typical work day at CTSI look like?

Since the Office of Discovery and Translation was only recently established, much of my time is spent working with Dr. Tucker LeBien to set up the operational components of the office. In addition, I regularly meet with faculty to discuss research ideas and interact with other offices and programs throughout the campus to explore new ways of identifying and supporting early stage translational research programs. We recently completed the review cycle for our newly initiated ODAT pilot grant program, so I have been busy reading proposals and overseeing the review process.

What do you like to do when you're not at CTSI?

I spend as much of my free time as possible with my husband and twin nine year old daughters. I am also active in a nonprofit organization that provides national leadership in the development of programs, policies, and services on behalf of drug-endangered children and their families. I have been involved in this organization for many years and currently serve as Chairman of the Board of Directors.

What is your favorite or current read?

Although my usual reading consists of scientific journal articles, at the request of one of my daughters, I recently read the book "Slob" by Ellen Potter. This poignant story illustrates many of the intense challenges faced by children growing up today. I highly recommend this book to middle grade children and their parents.

Favorite quote?

"You are today where your thoughts have brought you; you will be tomorrow where your thoughts take you."― James Allen, from "As a Man Thinketh"

On April 10, 2012, more than 120 people gathered to create and discuss 20 themes around Triple Aim innovation to improve the health of all Minnesotans. The conversations are only the beginning.

The UMN Clinical and Translational Science Institute is pleased to invite all Minnesota health care innovators to come together on Thursday, June 7th from 1pm - 5pm to continue the conversation.

The goal of this meeting will be to map the abstract themes and April 10th conversation outcomes to: 1) help the State of Minnesota respond to the CMS RFP for States; 2) begin to bring role clarity to designing and piloting the "Next Minnesota Model"; and 3) help the first round CMS Challenge Fund awardees succeed.

Read the complete report or an executive summary of our first meeting on April 10.

Click here to register by June 1st.

Questions? Contact Office of Community Engagement for Health Coordinator Andrea Leinberger-Jabari at 612-624-4247 or lein0072@umn.edu.