One of the most widely consumed substances in the world is coffee. Known by most of us for its smell, great taste, and awaking affects, coffee is a regular part of people's lives. On top of the great things we consciously know coffee does, it also decreases an individuals likely hood of developing Parkinson's disease, dementia, and Alzheimer's disease. Coffee's stimulating power, caffeine, has been well investigated however, it is still not clearly understood why coffee, as opposed to other caffeinated beverages, reduces one's chances of developing certain neurologically diseases.
Recently however, CYP1A1 and CAB39L were announced as possible candidates of the effectiveness of coffee at neurological disorder prevention because both showed activity when coffee entered into cells. CYP1A1 was down-regulated as coffee entered cells, while CAB39L was up-regulated around the same time. CYP1A1 is known to metabolize polycyclic aromatic hydrocarbons, coffee is known to have these polycyclic aromatic rings (interesting that this could be beneficial in some manner, ah?). CAB391L on the other hand is known as a calcium binding protein. A direct correlation has not been established between the activity of these genes from coffee consumption and the decrease in neurological diseases.
I thought this study was neat because it addressed a particular substance that was not an isolated chemical. The article seemed to still be very thorough in its methods even with an enormous sample size and rather difficult topic to approach. The article is fairly detailed, read up if you would like to know more.