A speeding train crashed into a bus carrying children and killed at least 51 in Assiut, Egypt, on Saturday morning, the Associated Press Reported.
Transport Minister Mohamed Rashad resigned, as did the head of railways authority, Reuters reported.
The report said the crash broke the bus in half and all but two of the children died. The children ranged in from 4 to 8 in age. A woman and a bus driver also died.
Egypt's transportation system has been subject of criticism for many years and Egyptian citizens have complained about the government's complacency with the system in place.
Families of the victims protested at the crash site. Doctors said many of the bodies were mutilated and dismembered.