Thursday, January 12, 2012
8:00 am - 2:00 pm
Location: Keller Hall 3-210 (first floor)
University of MN, Twin Cities East Bank Campus
The workshop is presented by the IPRIME Biomaterials and Pharmaceutical Materials (BPM) and Microstructured Polymers (MP) programs. Coordinators: Changquan Calvin Sun and Chris Macosko.
Description
Hot melt extrusion (HME) is gaining attention as a useful technique for enhancing delivery of poorly soluble drugs. During this workshop, leading scientists from both the pharmaceutical industry and academia will discuss both fundamental and practical aspects of HME.
Topics will include thermodynamics of polymer - drug interactions, solid-state characterization of extrudates, common polymers for HME, process development and optimization, mechanical properties of drug-polymer systems. IPRIME members with an interest in delivering poorly soluble drugs, HME formulation and process development, and applied polymer science are encouraged to attend.
To Attend
This workshop is free and open to IPrime member companies, invited guests, and University of Minnesota faculty, students, and staff.
Prospective IPrime members interested in attending an IPrime event as an invited guest should contact Bob Lewis, ph: 612-625-1269.
Morning
7:45
Continental breakfast and sign-in
8:25
Changquan Calvin Sun
University of Minnesota, Pharmaceutics
Welcome and Overview
8:30 Jim DiNunzio
Hoffmann-La Roche, Inc.
Melt Extrusion: Technology Overview and Applications for Early Stage Formulation Development
9:15
Chris Macosko and Frank Bates
University of Minnesota
Fundamentals of Polymer Additive Miscibility
10:00
Coffee break
10:30
Feng Qian
Bristol-Myers Squibb
An Underinvestigated Risk During Solid Dispersion Development: Drug-Polymer Mixing Uniformity
11:00
Shaukat Ali
BASF Corporation
Polymers for Hot Melt Extrusion Technology
11:30
Lunch break (box lunch provided with registration)
Afternoon
12:30
Peng Wang
University of Rhode Island
Extrusion for Drug Manufacturing - Material and Process Aspects
1:00
Changquan Calvin Sun
University of Minnesota
Mechanical properties of acetaminophen - PVPVA system
1:30
Panel Discussion
Current Challenges and Future Applications of Hot Melt Extrusion
2:00
Adjourn
Directions
Keller Hall
Campus maps
Light rail construction is underway at the University; please review details before arriving.
Accommodations
All offer University shuttle service
University Hotel - Minneapolis* 1-800-822-6757, East Bank campus
Days Inn University, (economy rates), 612-623-3999, East Bank campus
Holiday Inn Minneapolis Metrodome 612-333-4646, West Bank campus
* Closest to workshop
Taxis
Airport Shuttle, 612-827-7777
Airport Taxi, 612-721-0000
Yellow Cab, 612-788-8888
Atom