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Pharmaceutical Applications of Hot Melt Extrusion - Fundamental Aspects of Drug-Polymer Interaction and Process Development Workshop

Thursday, January 12, 2012
8:00 am - 2:00 pm
Location: Keller Hall 3-210 (first floor)
University of MN, Twin Cities East Bank Campus

The workshop is presented by the IPRIME Biomaterials and Pharmaceutical Materials (BPM) and Microstructured Polymers (MP) programs. Coordinators: Changquan Calvin Sun and Chris Macosko.

Hot melt extrusion (HME) is gaining attention as a useful technique for enhancing delivery of poorly soluble drugs. During this workshop, leading scientists from both the pharmaceutical industry and academia will discuss both fundamental and practical aspects of HME.

Topics will include thermodynamics of polymer - drug interactions, solid-state characterization of extrudates, common polymers for HME, process development and optimization, mechanical properties of drug-polymer systems. IPRIME members with an interest in delivering poorly soluble drugs, HME formulation and process development, and applied polymer science are encouraged to attend.

To Attend
This workshop is free and open to IPrime member companies, invited guests, and University of Minnesota faculty, students, and staff.

Prospective IPrime members interested in attending an IPrime event as an invited guest should contact Bob Lewis, ph: 612-625-1269.

Continental breakfast and sign-in

Changquan Calvin Sun
University of Minnesota, Pharmaceutics
Welcome and Overview

8:30 Jim DiNunzio
Hoffmann-La Roche, Inc.
Melt Extrusion: Technology Overview and Applications for Early Stage Formulation Development

Chris Macosko and Frank Bates
University of Minnesota
Fundamentals of Polymer Additive Miscibility

Coffee break

Feng Qian
Bristol-Myers Squibb
An Underinvestigated Risk During Solid Dispersion Development: Drug-Polymer Mixing Uniformity

Shaukat Ali
BASF Corporation
Polymers for Hot Melt Extrusion Technology

Lunch break (box lunch provided with registration)


Peng Wang
University of Rhode Island
Extrusion for Drug Manufacturing - Material and Process Aspects

Changquan Calvin Sun
University of Minnesota
Mechanical properties of acetaminophen - PVPVA system

Panel Discussion
Current Challenges and Future Applications of Hot Melt Extrusion



Keller Hall
Campus maps
Light rail construction is underway at the University; please review details before arriving.

All offer University shuttle service
University Hotel - Minneapolis* 1-800-822-6757, East Bank campus
Days Inn University, (economy rates), 612-623-3999, East Bank campus
Holiday Inn Minneapolis Metrodome 612-333-4646, West Bank campus
* Closest to workshop

Airport Shuttle, 612-827-7777
Airport Taxi, 612-721-0000
Yellow Cab, 612-788-8888

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