November 2011 Archives

SMART Syndrome

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There was a question last week about SMART Syndrome and potential therapies. While there have not been any experimentally tested treatments, in most of the case reports, patients are treated (if treatment is reported) with anti-epileptics. I have included a few of the more recent studies below, though there are also additional reports (cited in the below documents) from before the syndrome was proposed in 2003.

SMART syndrome: a late reversible complication after radiation therapy for brain tumours
SMART syndrome involves transient, reversible neurological dysfunction which may include migrainous headache, at times preceded by aura, prolonged hemispheric neurological impairment and sometimes seizure activity. Neuroimaging studies of patients with SMART syndrome typically show focal gyral thickening of the affected cortex and gyriform contrast enhancement.

Neurocognitive recovery in SMART syndrome: a case report

SMART: stroke-like migraine attacks after radiation therapy
Proposed diagnostic criteria:
SMART Criteria.jpg

Reversible, strokelike migraine attacks in patients with previous radiation therapy
Original article that first proposed the syndrome

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