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Kokkoli Research GroupDepartment of Chemical Engineering and Materials Science (CEMS)

Development and Characterization of an Aptamer Binding Ligand of Fractalkine Using Domain Targeted SELEX

Waybrant, B., Pearce, T.R., Wang, P., Sreevatsan, S., and Kokkoli, E.

Abstract

Fractalkine (FKN) is a unique cell surface protein with potential as a therapeutic target because of its role in inflammatory diseases and cancer. We developed an aptamer, named FKN-S2, with a dissociation constant of 3.4 ± 0.7 nM that is specific to the chemokine domain of fractalkine.

Citation
Waybrant, B., Pearce, T.R., Wang, P., Sreevatsan, S., and Kokkoli, E. "Development and Characterization of an Aptamer Binding Ligand of Fractalkine Using Domain Targeted SELEX", Chem. Comm., 2012, 48 (80): 10043-10045.
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