myU OneStop


Kokkoli Research GroupDepartment of Chemical Engineering and Materials Science (CEMS)

The Role of Spacers on the Self-Assembly of DNA Aptamer-Amphiphiles into Micelles and Nanotapes

Pearce, T.R., Waybrant, B., and Kokkoli, E.

Abstract

The self-assembly of single-stranded DNA (ssDNA) aptamer-amphiphiles was influenced by the choice of spacer used to link the hydrophobic tail and aptamer headgroup. Aptamer-amphiphiles without spacers or with hydrophilic spacers formed globular micelles while amphiphiles with hydrophobic spacers formed bilayer nanotapes, which are the first such structures formed by DNA-amphiphiles.

Citation
Pearce, T.R., Waybrant, B., and Kokkoli, E. "The Role of Spacers on the Self-Assembly of DNA Aptamer-Amphiphiles into Micelles and Nanotapes", Chem. Commun., 2014, 50 (2): 210 - 212.
Publisher's Link
PDF