another step in salamander-based regeneration research
Back in February of 2007, multiple articles were published on the attempts to stimulate limb regrowth in humans by using extracellular matrix from pig bladders. A recent study has gone a step farther detailing the isolation of the entire TGF-beta 1 gene in Axolotls. The TGF-beta 1 gene stimulates the regrowth of lost limbs in Axolotls. Humans have this gene but our cells produce scars instead of inducing regeneration. While application of the extracellular matrix reduced scarring and infection, the isolation of the TGF-beta 1 gene provides the possibility that manipulation of this gene could result in limb regrowth in humans.