The magazine has given Simpson the complete star package: a cover photo, a data sheet, an interview and a two-page centerfold, the New York Times said.
According to the New York Times, James Jellinek, the magazine's editorial editor, kept quiet about how much Simpson reveals in the November issue, but said, "It's very, very racy." Jellinek emphasized the cartoon form, BBC said.
"We knew that this would really appeal to the 20-something crowd," Playboy spokeswoman Theresa Hennessey said.
Since 2006, Playboy's circulation has slipped from 3.15 million to 2.6 million, the New York Times said. Putting Marge on the cover would ideally lower the magazine's median age to 35 while keeping its older subscribers, the New York Times reported.
Hugh Hefner, owner of Playboy Magazine, is a big fan of "The Simpsons" and even appeared in an episode in the early 1990s, BBC said.