We all know the feeling of being full. Especially when one overeats, their stomach hurts and they feel lethargic--as if the body is mad at how much we ate. Even in times when we don't eat, we generally have a sense of when we have gotten enough food. This feeling of satisfaction of hunger is an important body signal we wouldn't want to miss. This message is brought to you by a proud sponsor of the body, the "hunger hormone", leptin! The hormone "leptin" plays an important biological role in signaling to our hypothalamus and brain stem when to reduce appetite and increase energy use.
Most people who are obese tend to become more resistant to these leptin signals. In further researching the importance of leptin, a study was noted on leptin's role in weight loss published in an article by ABC News last summer.
Everyone has leptin. Well, almost everyone at least. Today there are only three known people who genetically lack the hormone. Bayrum Donsek, Elif Fakili, and Zeynep Fakili are three cousins from Turkey who by genetic mutation lack the hormone leptin; thus, they never experience feeling full, and have eaten themselves to very high weights. These three individuals went to UCLA to participate in a study where the subjects, being completely deficient of leptin, were injected with the hormone. Without even being told to eat less or exercise, the results proved to be incredibly significant, and all three lost a significant amount of weight.
As you can see, the hormones of our body are crucial, and are important messengers to keep us in homeostasis for maximum functioning! We can't go on well without them!!!