Memento is a well known movie directed by Christopher Nolan that depicts the life of Lenny who suffers from short-term memory loss. He still retains his previously long-term memories before he was afflicted with the condition, but he cannot make any new ones.
To see a trailer for Memento: http://www.youtube.com/watch?v=0vS0E9bBSL0
After watching Memento (if you haven't I highly recommend that you do) it begs the question of whether or not it accurately depicts what it would be like to suffer from short-term memory loss. I do not not have much background or experience with the constructs of memory so after doing some research I found that the scientific community generally agrees that Memento is one of the most realistic and accurate depictions of anterograde amnesia.
Here is an interesting article on the validity of Memento:
What makes Memento so powerful is that you are immersed into the life of Lenny and feel as if you are in his shoes. From the way the movie is presented in reverse you get a real sense of what it is like to suffer from anterograde amnesia. It is as if you partake in Lenny's thought process and are as clueless as he is of what just happened.
Here is an interesting graph of how time progresses in the movie:
In the end, Memento raises the question: what is real? Is our memory to be completely trusted? Can we always trust our interpretations of the world around us? Memory can be flawed so easily, how are we to know if anything in our past ever happened? In the end, as in the case of Lenny, reality is what we make it.