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U, Park Nicollet seek volunteers for diabetes drug study

The University of Minnesota and Park Nicollet International Diabetes Center are seeking volunteers to take part in a study comparing the long-term benefits and risks of four widely used diabetes drugs in combination with metformin, the most common first-line medication for treating type 2 diabetes.

The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study will manage participants’ diabetes medications and provide at least four medical visits per year free of charge throughout the study, but participants will receive other health care through their own providers.

“Type 2 diabetes is a progressive disease, and over time effective therapy usually requires the use of more than one medication,” says Elizabeth Seaquist, M.D., principal investigator of the U’s clinical site. “Patients and their caregivers have many options for treatment but have no evidence to tell them which combinations work best together. GRADE will provide this evidence and simplify the choices.”

Learn more about the study at

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