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Major grant funds stem cell research collaboration

Six University researchers will benefit from the NHLBI grant, including (from left) Jonathan Slack, Ph.D.; Michael Kyba, Ph.D.; Dan Kaufman, M.D., Ph.D.; Daniel Garry, M.D., Ph.D.; Jay Zhang, M.D., Ph.D.; and Doris Taylor, Ph.D. (not pictured). (Photo: Richard Anderson)

Most major medical discoveries don’t happen in a single lab; they result from close collaboration across multiple institutions. That’s why it was big news when University of Minnesota researchers learned in October that they had received a sevenyear collaboration grant to help develop the high-potential field of stem cell therapy.

With the grant from the National Heart, Lung, and Blood Institute (NHLBI), University researchers will partner with a research team from the University of Wisconsin-Madison to understand how and when stem cells commit to becoming a certain type of blood cell.

“What we want to know is, how do various stem cells decide to become blood or heart or blood vessels? How can we enhance that process so it becomes highly efficient and produces a large number of those cells?” says Daniel J. Garry, M.D., Ph.D., executive director of the Lillehei Heart Institute and leader of the University research team.

The collaboration award provides each institution with $750,000 per year and brings together researchers from the heart, lung, blood, and technology research fields. Scientists from partner institutions will meet several times a year to exchange ideas and discuss how they can accelerate one another’s work.

Jonathan Slack, Ph.D., director of the University’s Stem Cell Institute, was a pivotal partner in identifying ways to leverage the University’s strengths to make a standout grant application, Garry says.

“This was a golden opportunity for us,” Slack says. “We already had expertise in embryonic stem cell/iPS cell biology, hematopoietic development, cardiac development, decellularized organs, cell transplantation, and imaging technology—in other words, all the technology required.”

Philanthropy is another reason behind the University’s grant success. Last year the Engdahl Family Foundation funded an interdisciplinary study by cardiology professor Jay Zhang, M.D., Ph.D., and stem cell scientist Dan S. Kaufman, M.D., Ph.D., aimed at identifying which factors are important in promoting cardiac regeneration. That study provided preliminary data that made the University a strong contender for the NHLBI grant, Garry says.

“Gifts that support novel research ideas often set the table for our scientists to later earn much larger grants from agencies such as the NHLBI,” he says. “A gift to start-up research like this often gets a huge return on the donor’s investment.”

And thanks to the exchange of tools and information through the NHLBI-funded collaboration, the return on investment is only likely to grow.

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