Leptospirosis

Projects | Related Projects | GLEAN | Reports and Presentations | Links LeptospirosisLeptospirosis, an infection of worldwide public health importance, is caused by Leptospira bacteria that can be transmitted from animals to humans. Human infection can occur after contact with infected animals or with a Leptospira-contaminated environment usually associated with agricultural practices, contamination of household or recreational water, poor housing and waste disposal, and changes in the density or proximity of infected animal (rodents, domestic animals, and wildlife). The mechanisms involved in the transmission of the bacteria and the ecological and sociological factors that affect the likelihood of human infection are poorly understood. Leptospirosis
Projects Eco-epidemiology of Leptospirosis The goal is this research program is to understand how leptospirosis persists and is transmitted in ecologically distinct environments and populations, to quantify the relative importance of the multiple sources of infection, and to identify optimal surveillance, response and intervention programs. Broader impacts of this project include training of professionals in the area of emerging infectious diseases and global health, development of methodologies for studying the environmental sources of human infections, and the establishment of multinational and multidisciplinary partnerships for combating infectious diseases of global health importance. Eco-epidemiology of leptospirosis in Chile: Understanding transmission dynamics in distinct community types This project is funded by the Ecology of Infectious Program from National Science Foundation. The specific aims are:
  1. To identify and quantify the socio-ecological elements that regulate the distribution of Leptospira infection and environmental contamination in three different types of communities in southern Chile representing rural and urban environments.
  2. To identify effective intervention strategies to reduce animal and human leptospirosis in developing countries though the development of a mathematical transmission model.
The Specific Aims will be addressed through an ecosystem-based field study in Los Rios Region, Chile. In order to predict the risk of Leptospira transmission to humans, we will enroll households from distinct types of communities and characterize the distribution and genetic relatedness of Leptospira from humans, domestic and farm animals, rodents, and water in the study areas. The Leptospira data will be related to environmental, demographic, sociological, occupational, and climatic factors. Chile Leptospirosis Projects
Collaborating Institutions
  • Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile
  • Department of Ecology and Evolutionary Biology, University of California, Los Angeles
  • Epidemiology of Microbial Diseases, Yale School of Public Health
Collaborating Institutions
Related Projects Temporal patterns of Leptospira environmental contamination in rural villages from southern Chile The goal of this student project is to characterize changes over time in leptospira-contaminated water from a peri-domestic environment in rural households and what factors are correlated with the change. Funded is being provided by the Global Spotlight Program from the University of Minnesota. http://global.umn.edu/spotlight/index.html
Recent Reports and Presentations
  
March 2013 "Systematic literature review of leptospirosis outbreaks". 2nd Meeting of the Global Leptospirosis Environmental Action Network, Brasilia, Brazil.
  
March 2013 "Eco-epidemiology of leptospirosis in Latin America". 2nd Meeting of the Global Leptospirosis Environmental Action Network, Brasilia, Brazil.
  
April 2013 "The eco-epidemiology of leptospirosis; a neglected disease". College of Veterinary Medicine Seminar Series. University of Minnesota, St. Paul, Minnesota.
  
April 2013 "Zoonotic disease transmission in distinct socio-ecological systems; leptospirosis as an example". Conservation Ecology Graduate Program Seminar Series. University of Minnesota, St. Paul, Minnesota.
  
August 2013 "Eco-epidemiology of leptospirosis in rural Chile". XVI XLIX Congress of the Brazilian Society of Tropical Medicine. Campo Grande, Brazil. Leptospirosis Special Symposium.
  
October 2013 "Sero-epidemiology of canine leptospirosis in rural and slum communities from southern Chile".8th Meeting International Leptospirosis Society. Fukuoka, Japan.
  
October 2013 "Leptospira contamination in water from the peri-domestic environment in rural and slum communities from Chile".8th Meeting International Leptospirosis Society. Fukuoka, Japan.
  
November 2013 "Drivers of leptospirosis transmission at the human-animal interface in distinct community types".2nd One Health Summit, Global Risk Forum. Davos, Switzerland.

Important Links International Leptospirosis Society http://www.med.monash.edu.au/microbiology/staff/adler/ils.html Leptospirosis Burden Epidemiology Reference Group http://www.who.int/zoonoses/diseases/lerg/en/index.html Global Leptospirosis Environmental Action Network (GLEAN) http://www.glean-lepto.org/

Latest News

Diagnosis and Profiling of Leptospirosis Workshop at the Universiti Putra Malaysia
February 4-7, 2014 Organized by USAID-RESPOND project and the Malaysia One Health University Network (MyOHUN). Instructors: Claudia Munoz-Zanzi from University…

Leptospirosis Special Session at the One Health Summit 2013, Davos
The Special session "An Unrecognized One Health Threat: Leptospirosis" was organized by GLEAN. See the website for more information and…

Foro Nacional y Reunión Internacional de Leptospirosis - Nicaragua
Foro Nacional y Reunión Internacional de Leptospirosis - Nicaragua http://www.youtube.com/watch?v=HTquuP9Kphc&feature=player_detailpage…