October 2009 Archives

Ependymoblastoma

This 2 year old was noted to have a head tilt for 1 week.  A well-circumscribed, enhancing lesion near the foramina of Luschka displaced the pons.

ependymoblastomarosette copy.jpg mitotic copy.jpg ependymoblastoma.jpg
 

Meningioma with clear cell features

The patient is a 5 year old who had a meningioma involving the cavernous sinus at age 2 1/2.  The tumor recurred within 2 years and has not responded well to radiation therapy.
clearcellmeningi4x.jpg Thumbnail image for clearcell 20x.jpg clearcellmening40x.jpg
Clear cell meningioma:

  • Incidence: 0.2 % of all meningiomas, rarest variant
  • WHO Grade II
  • Age: Younger patients
  • Sex:Female predilection in Ped CCMs
  • Locations: Cerebellopontine angle and Intraspinal
  • Recurrence: High rate, up to 61%


Histology:  Solid, clear glycogen rich cells, round and innocuous nuclei, inconspicuous nucleoli,  lack mitotic activity,  distinctive hyalinised stroma.

Immunohistochemistry:  EMA +ve,Vimentin +ve, Inhibin -ve,GFAP -ve , PAS +ve diastase sensitive material.High MIB-1 LI accounts for the high-recurrence rate.

DDX:Differential diagnoses include microcystic meningioma, hemangioblastoma, clear cell ependymoma and metastatic carcinoma.

References: Greenfield's Neuropathology, Sixth Edition

1: Clear cell meningioma, an uncommon variant of meningioma: a clinicopathologic study of nine cases. J. Neurooncol. 2007 Feb;81(3):315-21.

About this Archive

This page is an archive of entries from October 2009 listed from newest to oldest.

September 2009 is the previous archive.

November 2009 is the next archive.

Find recent content on the main index or look in the archives to find all content.