The patient is a 5 year old who had a meningioma involving the cavernous sinus at age 2 1/2. The tumor recurred within 2 years and has not responded well to radiation therapy.
Clear cell meningioma:
Histology: Solid, clear glycogen rich cells, round and innocuous nuclei, inconspicuous nucleoli, lack mitotic activity, distinctive hyalinised stroma.
Immunohistochemistry: EMA +ve,Vimentin +ve, Inhibin -ve,GFAP -ve , PAS +ve diastase sensitive material.High MIB-1 LI accounts for the high-recurrence rate.
DDX:Differential diagnoses include microcystic meningioma, hemangioblastoma, clear cell ependymoma and metastatic carcinoma.
References: Greenfield's Neuropathology, Sixth Edition
1: Clear cell meningioma, an uncommon variant of meningioma: a clinicopathologic study of nine cases. J. Neurooncol. 2007 Feb;81(3):315-21.
- Incidence: 0.2 % of all meningiomas, rarest variant
- WHO Grade II
- Age: Younger patients
- Sex:Female predilection in Ped CCMs
- Locations: Cerebellopontine angle and Intraspinal
- Recurrence: High rate, up to 61%
Histology: Solid, clear glycogen rich cells, round and innocuous nuclei, inconspicuous nucleoli, lack mitotic activity, distinctive hyalinised stroma.
Immunohistochemistry: EMA +ve,Vimentin +ve, Inhibin -ve,GFAP -ve , PAS +ve diastase sensitive material.High MIB-1 LI accounts for the high-recurrence rate.
DDX:Differential diagnoses include microcystic meningioma, hemangioblastoma, clear cell ependymoma and metastatic carcinoma.
References: Greenfield's Neuropathology, Sixth Edition
1: Clear cell meningioma, an uncommon variant of meningioma: a clinicopathologic study of nine cases. J. Neurooncol. 2007 Feb;81(3):315-21.
