ec
calamitous(adjective): being, causing, or accompanied by calamity
(http://www.merriam-webster.com/dictionary/calamitous)
"Chances are that if countries begin deploying geoengineering systems, it will be because calamitous climate change is near at hand" ("A Last Resort Against Global Warming?" 4)
My grandma's hair feel out because it was calamitous to her chemotherapy treatment.