Public Lectures

Julie E. Buring, ScD, Tenth Annual Carl J. Martinson Lecture, April 7, 2006. University of Minnesota School of Public Health, Division of Epidemiology and Public Health.

Abstract: Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, with little effect on the risk of ischemic stroke and few data directly in women. For vitamin E, while there are suggestive data from basic research and observational studies, there have been few trials of long duration or in primary prevention. To address these questions, 39,876 initially healthy female health professionals 45 years of age or older were randomized into the Women's Health Study in a 2x2 factorial design, receiving 100 mg of aspirin on alternate days or placebo and 600 IU of natural-source vitamin E on alternate days or placebo, and followed for cardiovascular disease and cancer for an average of 10.1 years. The cardiovascular results of this trial for both aspirin and vitamin E will be given in this presentation.

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