The Crying of Lot 49 raises issues of communication, or rather failures of communication, in a chaotic and fragmented world. It also focuses on issues of science (i.e. Nefastis's machine and Dr. Hilarious's experiements), a study which exemplifies a highly ordered and comprehensible system. What is the significance of Pynchon's juxtaposition of these two worlds? Does communication in one world affect the other? Could he be showing how one world undermines the other?