The proposed constitutional amendment to define marriage as between a man and a woman failed to pass after elections Tuesday, the Star Tribune reported.
In a very close vote, with 99 percent of precincts reporting, supporters of the amendment reached only 48 percent, the Star Tribune reported.
The Pioneer Press reported that this historic defeat makes Minnesota the second state to defeat this amendment.
"Tonight Minnesota proved that love is bigger than government," said Minnesotans United for All Families campaign manager Richard Carlbom to the Pioneer Press.
The Minnesota Catholic Conference issued a statement Wednesday morning, according to the Star Tribune.
"Despite this setback, our efforts to promote and defend the cornerstone social institution of marriage will continue."