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New Obesity Drug

A new obesity drug, Tesofensine, produces weight loss twice that of currently approved obesity drugs, according to Danish researchers. Tesofensine works by suppressing hunger, leading to an energy deficit which burns off excess body fat.

This randomized-controlled trial in phase II prescribed 203 obese patients a low calorie diet and one of four different treatments for 24 weeks.

low calorie diet and placebo
tesofensine 0.25mg
tesofensine 0.5 mg
tesofensine 1.0 mg

The primary outcome was percentage change in bodyweight. A total of 161 patients completed the study.

Mean weight loss
placebo and diet: 2.2kg (5 lbs)
tesofensine 0.25mg: 6.7kg (15 lbs)
tesofensine 0.5mg: 6.7kg 11.3kg (25 lbs)
tesofensine 1.0mg: 12.8kg (28 lbs)

However this drug does seem to have side effects such as dry mouth, nausea, constipation, hard stools, diarrhoea, and insomnia.

The authors conclude that the 0.5mg dose of tesofensine is more promising than the 1.0mg dose because it produces a similar weight loss with less side-effects. They say: “We conclude that tesofensine 0.5 mg, once daily for 6 months, has the potential to produce twice the weight loss as currently approved drugs; however, larger phase III studies are needed to substantiate our findings.?

Source: http://www.sciencedaily.com/releases/2008/10/081022222907.htm


It's always a little scary when a new diet pill comes around that touts how you can use it for effective fat loss. The only real effective form of fat loss is a healthy diet, and an exercise program consisting of weights and cardio. That, and a positive attitude will take you a long way, and will result in a healthier, and more permanent form of weight loss.

Pharmaceutical diet pills can potentially cause psychological side effects as well as physical reactions. Acomplia was recently removed from the shelves after several years of circulation.
New diet pills that are being developed are being centred around appetite suppression - the problem with this genre is an obese person may override his or her hypothalamus over time and so not benefit.