
Chances are that most of us have heard of Alzheimer's disease before, and we may know a family member who suffers from the terrible disease. A startling statistic shows that Alzheimer's is the "fourth leading cause of death for those over 65. By the year 2040 an estimated 14 million will be living with the disease" ().
I personally find Alzheimer's to be a very interesting disease from a medical standpoint not only because it's found most often in older/senior adults, but because it's not caused by and bacteria or virus, but instead a plaque and protein buildup that's made inside the brain. Two or three hypothesis of how Alzheimer's disease originates have come about.
The first hypothesis is that of amyloid plaque. When amyloid is found in large quantities it will undergo a conformational change to accommodate the large number of molecules. However, if there are numerous amyloid's present then this conformation change results in the formation of a plaque which is made up of "mostly insoluble deposits of protein and cellular material outside and around neurons" These massive formations of amyloid are thought to be synthesized and cause a disruption of the brains "calcium ion homeostasis" and thus lead to cell death (which would be why we would see much darker almost completely occluded spots on an MRI of a patient with Alzeheimer's than of a brain scan of a normal brain).
There is another protein located in the brain that has been shown to be a contributor of Alzheimer's Disease. This protein is called "Tau." Tau's main function in a healthy brain is the stabilization of the brains cytoskeleton. However, the hypothesis is that when Tau is over synthesized, or even under-synthesized, as it is in a person with Alzheimer's disease, Tau itself causes a buildup and "tangles" neurons or collapses them. Unfortunately for your brain, this tangling/collapsing causes your neurons not to fire correctly. This improper firing causes the signs/symptoms that are well known with this disease: memory loss, learning, thinking and reasoning disabilities.
Researchers are having a difficult time with advancements on how to treat Alzheimer's disease because our brains are encased in what's called a "Blood Brain Barrier" which allows only very specific hormones and blood regulation through. Recent research at the Mayo Clinic in Rochester has biochemists attempting to engineer proteins that will be able to pass through our BBB and attach itself specifically to the amyloid/senile plaque areas so that scientists can image the areas via MRI (Magnetic Resonance Imaging).
In time, the Mayo Clinic also hopes it will be able to engineer a vaccine that will cease the amyloid/senile plaques from forming clumps in the brain.
1. Do you know of someone struggling with this terrible disease?
2. Did you find any of this information to be insightful?


Alzheimer's disease is a form of extreme dementia associated with progressive loss in memory, ability to speak, and ability to think and judge properly. These are very broad symptoms. This disease is relatively common among older people, especially those of age 60 or greater. AD is the most common form of Dementia. There are generally considered to be two types of AD: Early onset AD and Late onset AD. 












Dolphin trainers at Sea World live by this theory and their efforts pay off each time they perform a show. I find it very interesting that such an elementary concept is so effective. Something that takes five minute for a sitcom to introduce, humorously, can be directly applied to real life situations. As long as the specimens: the character or dolphins, are presented with a stimulus that ignites the response of pleasure/enjoyment: chocolate or a rub on the belly, the training is almost inevitable. These dolphins perform amazing feats and obey their trainers unbelievably well. I find enjoyment in discovering psychological ideas being implemented in the world around me.
I, myself, was included in that 30% and glad to find out I was not alone. When I was a young child, I sleepwalked frequently. My parents have numerous embarrassing stories of things that I did while sleepwalking, whether it be sitting in a dry bathtub pretending to take a bath or unknowingly getting ready for school, even though it was the middle of the night. I would have no recollection in the morning of my midnight escapades.







According to "The Secret You" it all starts in the Reticular Activating System, which is a group of diffused nerve cells in the brain stem. This sends projections to the relay system known as the Thalamus, which then sends these projections throughout the Cortex. Consciousness is constant activation of the Cortex. So when do we consider someone to be out of consciousness? Do we consider someone to be out of consciousness when they are in a vegetative state? A researcher from "The Secret You" video is finding evidence on the contrary. When people that are in vegetative states were asked to imagine themselves playing a tennis match the same part of their brain was activated as the healthy volunteers who were asked the same question. In a sense they were acknowledging that they were being asked a question and reacting to that question. Does this mean they still have consciousness? Is it wrong then to take someone off life support who can still process in their mind thier surroundings? When should people be considered brain dead or out of consciousness? I am interested in what people have to say on this topic.
Has this had a major impact on the belief of the unknown? If we do believe the teachings are relevant that may lead us down a different path, but ESP being featured in our book is not there to let us know the truth behind it but further more the reasoning of the crazy phenomenons people seem to have. Illusory correlation, recalling striking evidence as coincidences and ignore the other events that may harm this thought, may be an explanation to this extraordinary claim of being able to "predict" the future. Is this an intensive enough explanation? Have you ever had ESP feelings whether they be through a dream or a feeling of an event that occurred? And back to the article, does this topic have the solid evidence to be printed in scholarly text books and given to students as useful information? Those may be questions for us to answer ourselves depending on the extent in which we believe in ESP. 



