"Home"
Everyone has a different Idea of home. Some don't even have a place o actually call home, and others never want to leave.
The ideas of home are shaped by many different things, race class, and even gender. In Priscilla we watched a group of drag queens and one transsexual explore the road and find home on a bus. We saw how when someone endangers the ideas of traditional masuclinity and gender they are seen as inferior and therefore threatening of the so called normal person.
Although they were not your traditional males, seeing them on the road, and finally getting to their destination after being subjected to multiple hostilites was heartwarming. I was glad to see that they were determined to get where they were going and not let anyone get in the way of their destination. They didn't care that they had "Aids F-ers Go Home!!" written on their bus. They took this as an opportunity to make the bus even more fabulous, and even more fitting to their personalities.
They may have gotten a good fright here and there, but they learned from it, and bonded between each experience. They were also reminded that the city is more of a safe zone, because of the higher tolerance level than that of all the hetero-normativity in the rural and desert areas.
One cannot live there life in fear, this was demonstrated perfectly by this movie.